ArticleBMC pediatrics2024
A case of pioneering subcutaneous implantable cardioverter defibrillator intervention in Timothy syndrome.
Article in BMC pediatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Interpretable Semi-federated Learning for Multimodal Cardiac Imaging and Risk Stratification: A Privacy-Preserving Framework.Journal of imaging informatics in medicine · 2026Article
- New Machine Learning Method for Medical Image and Microarray Data Analysis for Heart Disease Classification.Journal of imaging informatics in medicine · 2026Article
- Optimized Feature Selection and Deep Neural Networks to Improve Heart Disease Prediction.Journal of imaging informatics in medicine · 2026Article
- Integrating ECG-derived features with conventional CVD risk models.Scientific reports · 2025Article
- IoT assisted fetal health classification using mother optimization algorithm with deep learning approach on cardiotocogram data.Scientific reports · 2025Article
- Evaluation of antiarrhythmia drug through QSPR modeling and multi criteria decision analysis.Scientific reports · 2025Article
- Enhancing cardiac disease detection via a fusion of machine learning and medical imaging.Scientific reports · 2025Article
- Cardioprotective effects of carvacrol in the isoproterenol-induced myocardial infarction model.BMC pharmacology & toxicology · 2025Article
- Effectiveness of machine learning models in diagnosis of heart disease: a comparative study.Scientific reports · 2025Article
- Longevity mechanisms in cardiac aging: exploring calcium dysregulation and senescence.Biogerontology · 2025Review
- ECG-based heart arrhythmia classification using feature engineering and a hybrid stacked machine learning.BMC cardiovascular disorders · 2025Article
- Optimized machine learning framework for cardiovascular disease diagnosis: a novel ethical perspective.BMC cardiovascular disorders · 2025Article
- Explainable AI-driven intelligent system for precision forecasting in cardiovascular disease.Frontiers in medicine · 2025Article
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Authors and funding
10 authors.
Funding
Abstract
This case report presents a notable instance of subcutaneous implantable cardioverter defibrillator (S-ICD) implantation in a 9-year-old patient diagnosed with Timothy syndrome (TS), which is a rare condition characterized by mutations in the CACNA1c gene. Conventional therapies often have limited efficacy in managing TS. This case is significant, as it represents the youngest age for S-ICD implantation recorded in mainland China. While the absence of ventricular arrhythmias during hospitalization and follow-up is encouraging, it is not sufficient to conclusively establish the safety and feasibility of this intervention in young TS patients. Further research is needed to evaluate the long-term outcomes and to consider S-ICD as a potential standard treatment option for TS. Additionally, there is a need for a more detailed exploration of the molecular mechanisms underlying gene therapy and personalized interventions.
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