Evidence map›Paper›PMID 39533181›Full record

SynthesisBMC anesthesiology2024

Do patients receiving extracorporeal membrane-oxygenation need antibiotic prophylaxis? A systematic review and meta-analysis on 7,996 patients.

Daniele Orso, Caterina Maria Fodale, Sara Fossati, Sergio Venturini, Federico Fonda, Francesco Cugini, Irene Comisso, Massimo Crapis, Luisa Cacciavillani, Tiziana Bove

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC anesthesiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Daniele OrsoDepartment of Emergency, University Hospital of Udine, Azienda Sanitaria Universitaria Friuli Centrale, "Santa Maria della Misericordia", Piazzale Santa Maria della Misericordia 15, Udine, 33100, Italy. sd7782.do@gmail.com.
Caterina Maria FodaleDepartment of Cardio-Thoraco-Vascular Sciences and Public Health, University Hospital of Padua, Via Giustiniani, 2, Padua, 35128, Italy.
Sara FossatiDepartment of Emergency, University Hospital of Udine, Azienda Sanitaria Universitaria Friuli Centrale, "Santa Maria della Misericordia", Piazzale Santa Maria della Misericordia 15, Udine, 33100, Italy.
Sergio VenturiniDepartment of Infectious Diseases, Community Hospital of Pordenone, Azienda Sanitaria Friuli Occidentale, "Santa Maria degli Angeli", Via Montereale 34, Pordenone, 33170, Italy.
Federico FondaDepartment of Emergency, University Hospital of Udine, Azienda Sanitaria Universitaria Friuli Centrale, "Santa Maria della Misericordia", Piazzale Santa Maria della Misericordia 15, Udine, 33100, Italy.
Francesco CuginiDepartment of Emergency Medicine, Community Hospital of San Daniele del Friuli "Ospedale Sant'Antonio", Azienda Sanitaria Friuli Centrale, Viale Trento Trieste 33, San Daniele del Friuli, 33038, Italy.
Irene ComissoDepartment of Emergency, University Hospital of Udine, Azienda Sanitaria Universitaria Friuli Centrale, "Santa Maria della Misericordia", Piazzale Santa Maria della Misericordia 15, Udine, 33100, Italy.
Massimo CrapisDepartment of Infectious Diseases, Community Hospital of Pordenone, Azienda Sanitaria Friuli Occidentale, "Santa Maria degli Angeli", Via Montereale 34, Pordenone, 33170, Italy.
Luisa CacciavillaniDepartment of Cardio-Thoraco-Vascular Sciences and Public Health, University Hospital of Padua, Via Giustiniani, 2, Padua, 35128, Italy.
Tiziana BoveDepartment of Emergency, University Hospital of Udine, Azienda Sanitaria Universitaria Friuli Centrale, "Santa Maria della Misericordia", Piazzale Santa Maria della Misericordia 15, Udine, 33100, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients undergoing Extracorporeal Membrane Oxygenation (ECMO) are particularly susceptible to infections: 42% experience sepsis and 26% develop a nosocomial infection (NI). Whether antibiotic prophylaxis is effective in reducing mortality and its effects on the rate of NIs is currently unclear. RESEARCH QUESTION: Can antibiotic prophylaxis decrease 30-day mortality for patients on ECMO? Can antibiotic prophylaxis prevent the occurrence of NIs in these patients? STUDY DESIGN AND

methodsA systematic review and meta-analysis was conducted. We searched PubMed, Scopus, and CINAHL libraries from inception to June 12, 2024. Two researchers were involved in abstract screening and three researchers were involved in full text selection.

resultsA pooled population of 7,996 patients is represented by 5 retrospective studies. Reported mortality ranges between 46 and 58% and the NIs rate is between 14 and 62%. Regarding 30-day mortality, the random-effects model (I

conclusionAccording to a very low degree of certainty, antibiotic prophylaxis appears to have no impact on the 30-day mortality rate of ECMO recipients. The risk of NIs seems to decrease with antibiotic prophylaxis, even though the NNT is high. Prospective high-quality studies that address these specific clinical questions are necessary. CLINICAL

trial registrationPROSPERO: International prospective register of systematic reviews, 2024, CRD42024567037.

Indexed as

Antibiotic ProphylaxisCross InfectionExtracorporeal Membrane OxygenationAnti-Bacterial AgentsHumansSepsisAnti-Bacterial AgentsAntibiotic prophylaxisECMOMeta-analysisMortalityNosocomial infection

Identifiers

PMID39533181
PMCPMC11556216

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.