ArticleNature immunology2025
Disease-associated B cells and immune endotypes shape adaptive immune responses to SARS-CoV-2 mRNA vaccination in human SLE.
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Article in Nature immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers.
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13citing papers in PubMed
–field-weighted citation impact
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Who cites it
13 citing papers in PubMed.
- Single-Cell Transcriptomic Profiling Identifies B Cell-Intrinsic Dysregulation of Sphingolipid Biosynthesis and Could Be Improved by Inhibiting UGCG in Primary Immune Thrombocytopenia.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Vaccine elicitation of HIV broadly neutralizing antibodies from genome-edited B cells in non-human primates and derived lymphoid organoids.Gene therapy · 2026Article
- Autoreactive B cells in systemic lupus erythematosus: insights from integrative multi-omics analyses.Inflammation and regeneration · 2026Review
- Longitudinal clinical proteomics reveals pneumonia type-specific protein biomarkers and autoantibodies.JCI insight · 2026Article
- Defective B cell tolerance in SLE lymph nodes underpins VHmedRxiv : the preprint server for health sciences · 2026Article
- Dysregulation of anti-Ro60 B cell autoreactivity in systemic lupus erythematosus.bioRxiv : the preprint server for biology · 2026Article
- Germinal-centre and extrafollicular B cell pathways in systemic lupus erythematosus.Nature reviews. Rheumatology · 2026Review
- From Innate to Adaptive: Paradigm Shifts and Frontier Challenges in Next-Generation Vaccine Design.Vaccines · 2026Review
- Longitudinal profiling of antigen receptor gene repertoire dynamics in kidney transplant recipients after multiple SARS-CoV-2 vaccinations.ImmunoHorizons · 2026Article
- Longitudinal clinical proteomics reveals pneumonia type-specific protein biomarkers and autoantibodies.medRxiv : the preprint server for health sciences · 2026Article
- BAFF-R expression as a potential biomarker associated with COVID-19 vaccine non-responsiveness in antibody-deficient patients.Clinical and experimental immunology · 2026Article
- Genetic Evidence Linking Immune Cell Subsets to Psoriatic Arthritis Susceptibility: A Mendelian Randomization Study.Psoriasis (Auckland, N.Z.) · 2026Article
- Dysregulated inflammation in solid tumor malignancy patients shapes polyfunctional antibody responses to COVID-19 vaccination.NPJ vaccines · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
31 authors.
Caterina E FalitiDepartment of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University, Atlanta, GA, USA.ORCID http://orcid.org/0000-0003-0487-1914
Trinh T P VanDepartment of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University, Atlanta, GA, USA.
Fabliha A AnamDepartment of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University, Atlanta, GA, USA.
Narayanaiah CheedarlaDepartment of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA.
M Elliott WilliamsDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA.ORCID http://orcid.org/0000-0001-8271-3394
Ashish Kumar MishraDivision of Viral Products, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration, Silver Spring, MD, USA.
Sabeena Y UsmanDepartment of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University, Atlanta, GA, USA.
Matthew C WoodruffDepartment of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University, Atlanta, GA, USA.
Geoff KrakerDotmatics, Inc., Boston, MA, USA.
Martin C RunnstromDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University, Atlanta, GA, USA.
Shuya KyuDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University, Atlanta, GA, USA.
Daniel SanzDepartment of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University, Atlanta, GA, USA.
Hasan AhmedDepartment of Biology, Emory University, Atlanta, GA, USA.
Midushi GhimireDepartment of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University, Atlanta, GA, USA.
Andrea Morrison-PorterDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University, Atlanta, GA, USA.
Hannah QuehlDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University, Atlanta, GA, USA.
Natalie S HaddadDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-1348-3094
Weirong ChenDepartment of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University, Atlanta, GA, USA.
Suneethamma CheedarlaDepartment of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA.
Andrew S NeishDepartment of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA.
John D RobackDepartment of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA.
Rustom AntiaDepartment of Biology, Emory University, Atlanta, GA, USA.ORCID http://orcid.org/0000-0001-7991-614X
Jennifer HomDepartment of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University, Atlanta, GA, USA.
Christopher M TiptonDepartment of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University, Atlanta, GA, USA.
John M LindnerBioMed X Institute, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-4940-5354
Eliver GhosnDepartment of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University, Atlanta, GA, USA.ORCID http://orcid.org/0000-0001-7258-906X
Surender KhuranaDivision of Viral Products, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration, Silver Spring, MD, USA.ORCID http://orcid.org/0000-0002-0593-7965
Christopher D ScharerDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA.ORCID http://orcid.org/0000-0001-7716-8504
Arezou KhosroshahiDepartment of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University, Atlanta, GA, USA.
F Eun-Hyung LeeDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-6133-5942
Ignacio SanzDepartment of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University, Atlanta, GA, USA. Ignacio.sanz@emory.edu.ORCID http://orcid.org/0000-0003-4182-587X
Funding
Regulation of B cell Responses in SLE and Other Autoimmune DiseasesU19AI110483 · NIAID · EMORY UNIVERSITY · PI JEREMY M. BOSS · 2014 to 2026
$76.6MRegulation of Pathogenic Plasma Cells in Human SLEP01AI125180 · NIAID · EMORY UNIVERSITY · PI Ignacio E. Sanz · 2016 to 2026
$28.2MProject-004U54CA260563 · NCI · EMORY UNIVERSITY · PI DHODAPKAR, MADHAV V, SANZ, IGNACIO E. · 2020 to 2024
$10.2MDivision of Intramural Research, National Institute of Allergy and Infectious Diseases (Division of Intramural Research of the NIAID) U19-AI110483Division of Intramural Research, National Institute of Allergy and Infectious Diseases (Division of Intramural Research of the NIAID) U54- 762 CA260563-01NCI NIH HHS U54 CA260563NIAID NIH HHS P01 AI125180NIAID NIH HHS U19 AI110483U.S. Department of Health & Human Services | U.S. Food and Drug Administration (U.S. Food & Drug Administration) GCBER005U.S. Department of Health & Human Services | U.S. Food and Drug Administration (U.S. Food & Drug Administration) GCBER008
Abstract
Severe acute respiratory syndrome coronavirus 2 mRNA vaccination has reduced effectiveness in certain immunocompromised individuals. However, the cellular mechanisms underlying these defects, as well as the contribution of disease-induced cellular abnormalities, remain largely unexplored. In this study, we conducted a comprehensive serological and cellular analysis of patients with autoimmune systemic lupus erythematosus (SLE) who received the Wuhan-Hu-1 monovalent mRNA coronavirus disease 2019 vaccine. Our findings revealed that patients with SLE exhibited reduced avidity of anti-receptor-binding domain antibodies, leading to decreased neutralization potency and breadth. We also observed a sustained anti-spike response in IgD
Indexed as
Antibodies, ViralB-LymphocytesCOVID-19COVID-19 VaccinesLupus Erythematosus, SystemicSARS-CoV-2Spike Glycoprotein, CoronavirusAdaptive ImmunityAdultAntibodies, Monoclonal, HumanizedAntibodies, NeutralizingFemaleHumansImmunologic MemoryMaleMiddle AgedAntibodies, Monoclonal, HumanizedAntibodies, NeutralizingAntibodies, ViralbelimumabCOVID-19 VaccinesmRNA VaccinesSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2
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