Evidence map›Paper›PMID 39532941›Full record

ArticleScientific reports2024

Prone positioning is associated with increased insulin requirements in mechanically ventilated patients with COVID-19.

Harry Griffiths, Amy Cardwell, Max Richardson, Meg Barne, Bogdan Petrisor, Ammara Usman, Laura Heales, Julia Calvo Latorre, Vishakha Bansiya, Razeen Mahroof and 5 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Harry GriffithsJohn Farman Intensive Care Unit, Addenbrooke's Hospital, Cambridge, UK.
Amy CardwellGrange University Hospital, Cwmbran, Wales, UK.
Max RichardsonIntegrated Critical Care Unit, Sunderland Royal Hospital, Sunderland, UK.
Meg BarneJohn Farman Intensive Care Unit, Addenbrooke's Hospital, Cambridge, UK.
Bogdan PetrisorJohn Farman Intensive Care Unit, Addenbrooke's Hospital, Cambridge, UK.
Ammara UsmanJohn Farman Intensive Care Unit, Addenbrooke's Hospital, Cambridge, UK.
Laura HealesDepartment of Anaesthetics & Intensive Care Medicine, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Julia Calvo LatorreDepartment of Diabetes & Endocrinology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Vishakha BansiyaDepartment of Diabetes & Endocrinology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Razeen MahroofJohn Farman Intensive Care Unit, Addenbrooke's Hospital, Cambridge, UK.
Tamas SzakmanyGrange University Hospital, Cwmbran, Wales, UK.
Daniel MartinPeninsula Medical School, University of Plymouth, John Bull Building, Plymouth, UK.
Anthony RostronIntegrated Critical Care Unit, Sunderland Royal Hospital, Sunderland, UK.
Andrew Conway MorrisJohn Farman Intensive Care Unit, Addenbrooke's Hospital, Cambridge, UK. ac926@cam.ac.uk.
Sam LockhartJohn Farman Intensive Care Unit, Addenbrooke's Hospital, Cambridge, UK. sl908@medschl.cam.ac.uk.

Funding

Medical Research Council MR/V006118/1Wellcome TrustWellcome Trust 225479/Z/22
6 · The paper itself

Abstract

Stress hyperglycaemia is common in critical illness. We have previously observed that increasing severity of respiratory failure in patients with severe COVID-19 is associated with increased insulin demand. Given previously reported direct effects of hypoxia on insulin action, we reasoned that rapid improvements in oxygenation following prone positioning may improve insulin sensitivity and increase risk of hypoglycaemia. A retrospective multi-centre service evaluation comparing blood glucose and insulin administration in patients with COVID-19 pneumonitis receiving prone mechanical ventilation, comparing the 16 h pre-prone and 16 h post-prone time periods. 155 patients were included in this analysis. Oxygenation improved significantly following prone positioning (change in SpO

Indexed as

Blood GlucoseCOVID-19InsulinRespiration, ArtificialAgedFemaleHumansHyperglycemiaHypoglycemiaMaleMiddle AgedPatient PositioningProne PositionRetrospective StudiesSARS-CoV-2Blood GlucoseInsulinCOVID-19Critical illnessGlucose metabolismInsulinProne ventilation

Identifiers

PMID39532941
PMCPMC11557589

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.