Evidence map›Paper›PMID 39532925›Full record

ArticleScientific reports2024

Low fluid shear stress promotes chondrocyte proliferation and extracellular matrix secretion by downregulating mir-143-3p and activating the ERK5/KLF4 signaling pathway.

Jun Zhao, Yayi Xia, Jinwen He

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jun ZhaoDepartment of Orthopaedics, Lanzhou University Second Hospital, #82 Cuiyingmen, Lanzhou, 730000, Gansu, China.
Yayi XiaDepartment of Orthopaedics, Lanzhou University Second Hospital, #82 Cuiyingmen, Lanzhou, 730000, Gansu, China. xiayy_lzu@126.com.
Jinwen HeDepartment of Orthopaedics, Lanzhou University Second Hospital, #82 Cuiyingmen, Lanzhou, 730000, Gansu, China.

Funding

Cuiying Scientific and Technological Innovation Program of Lanzhou University Second Hospital CY2021-MS-A07Lanzhou Science and Technology Plan Program 2021-RC-102Natural Science Foundation of Gansu Province 22JR5RA943、22JR5RA956The National Natural Science Foundation of China 81874017, 81960403 and 82060405
6 · The paper itself

Abstract

Low fluid shear stress (FSS, ≤ 2 dyn/cm2) has been shown to exert protective effects on chondrocytes, but the underlying molecular mechanisms remain unclear. This study aimed to elucidate the mechanisms by which FSS promotes chondrocyte proliferation and extracellular matrix (ECM) stability. We exposed SW1353 chondrocytes to low FSS (1.8 dyn/cm

Indexed as

Cell ProliferationChondrocytesDown-RegulationExtracellular MatrixKruppel-Like Factor 4Kruppel-Like Transcription FactorsMicroRNAsMitogen-Activated Protein Kinase 7Signal TransductionStress, MechanicalCell LineHumansKLF4 protein, humanKruppel-Like Factor 4Kruppel-Like Transcription FactorsMAPK7 protein, humanMicroRNAsMIRN143 microRNA, humanMitogen-Activated Protein Kinase 7ChondrocyteExtracellular signal-regulated kinase 5Fluid shear stressMiR-143-3pProliferation

Identifiers

PMID39532925
PMCPMC11557884

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.