Evidence map›Paper›PMID 39532922›Full record

ArticleScientific reports2024

METTL3 alters capping enzyme expression and its activity on ribosomal proteins.

Daniel Del Valle-Morales, Giulia Romano, Giovanni Nigita, Michela Saviana, Alessandro La Ferlita, Patricia Le, Rachel Brown, Lavender Micalo, Howard Li, Patrick Nana-Sinkam and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. NImmunity, inflammation and disease · 2024
    Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Daniel Del Valle-MoralesDepartment of Internal Medicine, Division of Pulmonary Diseases and Critical Care Medicine, Virginia Commonwealth University, Richmond, VA, 23298, USA.
Giulia RomanoDepartment of Internal Medicine, Division of Pulmonary Diseases and Critical Care Medicine, Virginia Commonwealth University, Richmond, VA, 23298, USA.
Giovanni NigitaDepartment of Cancer Biology and Genetics and Comprehensive Cancer Center, The Ohio State University, Columbus, OH, 43210, USA.
Michela SavianaDepartment of Internal Medicine, Division of Pulmonary Diseases and Critical Care Medicine, Virginia Commonwealth University, Richmond, VA, 23298, USA.
Alessandro La FerlitaDepartment of Internal Medicine, Division of Medical Oncology, The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
Patricia LeDepartment of Internal Medicine, Division of Pulmonary Diseases and Critical Care Medicine, Virginia Commonwealth University, Richmond, VA, 23298, USA.
Rachel BrownDepartment of Internal Medicine, Division of Pulmonary Diseases and Critical Care Medicine, Virginia Commonwealth University, Richmond, VA, 23298, USA.
Lavender MicaloDepartment of Internal Medicine, Division of Pulmonary Diseases and Critical Care Medicine, Virginia Commonwealth University, Richmond, VA, 23298, USA.
Howard LiDepartment of Internal Medicine, Division of Pulmonary Diseases and Critical Care Medicine, Virginia Commonwealth University, Richmond, VA, 23298, USA.
Patrick Nana-SinkamDepartment of Internal Medicine, Division of Pulmonary Diseases and Critical Care Medicine, Virginia Commonwealth University, Richmond, VA, 23298, USA.
Mario AcunzoDepartment of Internal Medicine, Division of Pulmonary Diseases and Critical Care Medicine, Virginia Commonwealth University, Richmond, VA, 23298, USA. mario.acunzo@vcuhealth.org.

Funding

The Role of Non-Coding RNA Editing in MET Signaling in NSCLCR21CA277525 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI ACUNZO, MARIO · 2023 to 2024
$403k
American Lung Association LCDA-922902NCI NIH HHS R21 CA277525NIH HHS NIH 1R21CA277525-01
6 · The paper itself

Abstract

The 5' cap, catalyzed by RNA guanylyltransferase and 5'-phosphatase (RNGTT), is a vital mRNA modification for the functionality of mRNAs. mRNA capping occurs in the nucleus for the maturation of the functional mRNA and in the cytoplasm for fine-tuning gene expression. Given the fundamental importance of RNGTT in mRNA maturation and expression there is a need to further investigate the regulation of RNGTT. N6-methyladenosine (m

Indexed as

MethyltransferasesRibosomal ProteinsRNA, Messenger3' Untranslated RegionsAdenosineHumansMethylationmRNA GuanylyltransferasesNucleotidyltransferasesRibosomal Protein S6 Kinases, 70-kDaRNA CapsTOR Serine-Threonine Kinases3' Untranslated RegionsAdenosineMethyltransferasesMETTL3 protein, humanmRNA GuanylyltransferasesMTOR protein, humanN-methyladenosineNucleotidyltransferasesRibosomal ProteinsRibosomal Protein S6 Kinases, 70-kDaRNA CapsRNA, MessengerTOR Serine-Threonine Kinasesm6AmRNA decayPost‐transcriptional regulationRNA cappingRNA methylationRNGTT

Identifiers

PMID39532922
PMCPMC11557883

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.