ArticleNature communications2024
Complement and microglia activation mediate stress-induced synapse loss in layer 2/3 of the medial prefrontal cortex in male mice.
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Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29 citing papers in PubMed.
- From mitochondria to innate immunity: The mtDNA-driven cGAS/STING-NLRP3 cascade and its therapeutic implications in neurodegenerative diseases (Review).Experimental and therapeutic medicine · 2026Review
- Small-Molecule NANT Therapeutics Targeting the Brain-Immune Axis in Alzheimer's Disease: Mechanisms, Clinical Progress, and Translational Challenges.Molecules (Basel, Switzerland) · 2026Review
- Parvalbumin interneurons under stress: converging mechanisms of vulnerability.The international journal of neuropsychopharmacology · 2026Review
- Liver-derived complement component 3 promotes the susceptibility to stress-induced depression by impairing blood-brain barrier integrity.Molecular psychiatry · 2026Article
- Repetitive Transcranial Magnetic Stimulation of the mPFC Ameliorates Stress-Induced Hyperalgesia by Alleviating Microglia Activation in Rats.Brain and behavior · 2026Article
- Distinct Transcriptomic Signatures of HIV-1 Tat and gp120 Uncover Differential Neuroimmune Vulnerability in aCurrent issues in molecular biology · 2026Article
- Neuroimmune mechanisms in PTSD: inflammatory heterogeneity, circuit dysfunction, and biomarker-based subtypes.Molecular biology reports · 2026Review
- From classic circuits to novel mechanisms: How lncRNA, neuroinflammation, and iPSC models address the translational crisis in PTSD research.Comprehensive psychoneuroendocrinology · 2026Review
- Targeting central immune signaling enhances the effects of methylphenidate in alleviating apathy-like behavior in 5xFAD mice.Scientific reports · 2026Article
- Neural impairments caused by energy storage material NCM811 via aberrated synaptic pruning: role of Th17 cells in microglia polarization.Journal of neuroinflammation · 2026Article
- Age-related transcriptional drift and physiological adaptation in long-living Ames dwarf skeletal muscle.NAR molecular medicine · 2026Article
- Panacis Quinquefolii Radix Polysaccharides Alleviate Depressive-Like Behaviors in Chronic Unpredictable Mild Stress-Induced Mice by Suppressing Complement C1Q/C3-Mediated Microglial Synaptic Pruning and Modulating Gut Microbiota.CNS neuroscience & therapeutics · 2026Article
- Axonopathy: mechanisms and potential therapeutic targets for neurodegenerative diseases.Translational neurodegeneration · 2026Review
- Ozone-induced cognitive deficits are mediated by the liver-brain axis: peripheral complement C3 triggers microglial synaptic phagocytosis.Journal of neuroinflammation · 2026Article
- Wuji Pill andFrontiers in microbiology · 2026Article
- The potential role of aberrant microglial synaptic pruning in the neurodevelopmental pathogenesis of tourette syndrome.Frontiers in neuroscience · 2026Review
- Regulatory T cells promote microglia-mediated synapse engulfment and functional recovery via the OPN-CD74 axis after spinal cord injury in mice.Journal of neuroinflammation · 2025Article
- Tactile stimulation reverses painful stimuli outcomes via PVN-VTA oxytocin circuitry and dopaminergic regulation.Communications biology · 2025Article
- NADPH alleviates LPS-induced neuropathology and depression-like behaviors by suppressing microglial inflammatory response.Translational psychiatry · 2025Article
- Temporal Progression of Recognition Memory Impairment, Astrogliosis, and Cholinergic Dysfunction in the Streptozotocin Rat Model of Sporadic Alzheimer's Disease.International journal of molecular sciences · 2025Article
Corrections and comments
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Authors and funding
12 authors.
Haven Tillmon *Department of Pharmacology, University of Texas Health at San Antonio, San Antonio, TX, 78229, USA.
Breeanne M Soteros *Department of Pharmacology, University of Texas Health at San Antonio, San Antonio, TX, 78229, USA.ORCID 0000-0002-4714-5165
Liang Shen *Institute of Neuroscience, Soochow University, Suzhou, 215123, China.
Qifei Cong *Institute of Neuroscience, Soochow University, Suzhou, 215123, China.
Mackenna WolletDepartment of Cellular and Integrative Physiology, University of Texas Health at San Antonio, San Antonio, TX, 78229, USA.
Julianne GeneralDepartment of Pharmacology, University of Texas Health at San Antonio, San Antonio, TX, 78229, USA.
Hanna ChinUniversity of Rochester, Rochester, NY, 14627, USA.
John Beichen LeeLong School of Medicine, University of Texas Health at San Antonio, San Antonio, TX, 78229, USA.
Flavia R CarrenoDepartment of Pharmacology, University of Texas Health at San Antonio, San Antonio, TX, 78229, USA.
David A MorilakDepartment of Pharmacology, University of Texas Health at San Antonio, San Antonio, TX, 78229, USA.ORCID 0000-0001-6689-6258
Jun Hee KimDepartment of Cellular and Integrative Physiology, University of Texas Health at San Antonio, San Antonio, TX, 78229, USA.ORCID 0000-0003-0207-8410
Gek Ming SiaDepartment of Cellular and Integrative Physiology, University of Texas Health at San Antonio, San Antonio, TX, 78229, USA. siag@uthscsa.edu.ORCID 0000-0001-9333-0065
Funding
TISSUE CULTURE---COREP30CA054174 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Lei Zheng · 1991 to 2026
$59.1MPrefrontal cortex and stress reactivityR01MH053851 · NIMH · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI MORILAK, DAVID A · 2002 to 2023
$6.4MRole of Adaptive Myelination in Auditory Brain PlasticityR01DC018797 · NIDCD · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Jun Hee Kim · 2021 to 2026
$2.9MRole of SCN2A in Myelination and Neural Circuit Development in Autism Spectrum DisorderR01DC019371 · NIDCD · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI KIM, JUN HEE · 2021 to 2025
$2.6MSushi domain proteins as synapse protective factors in brain development and agingR01NS112389 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI SIA, GEK MING · 2019 to 2023
$1.8MIntegrated Graduate Training Program in Neuroscience, UTHSCSAT32NS082145 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI David A Morilak · 2013 to 2026
$1.5MIllumina NovaSeq 6000 Sequencing SystemS10OD030311 · OD · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI LAI, ZHAO · 2021 to 2021
$600kFACSAria Fusion cell sorter for Flow Cytometry Shared ResourceS10OD030432 · OD · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI BERTON, MICHAEL T · 2022 to 2022
$596kNovel mechanisms contributing to the antidepressant-like response of pharmacological hippocampal activationR21MH113899 · NIMH · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CARRENO, FLAVIA · 2018 to 2019
$419kHeterogeneous microglia activation mediates stress-induced changes in neural circuitry.R21MH132078 · NIMH · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI BHAT, MANZOOR A. · 2023 to 2023
$410kNCI NIH HHS P30 CA054174NIDCD NIH HHS R01 DC018797NIDCD NIH HHS R01 DC019371NIH HHS S10 OD030311NIH HHS S10 OD030432NIMH NIH HHS R01 MH053851NIMH NIH HHS R21 MH113899NIMH NIH HHS R21 MH132078NINDS NIH HHS R01 NS112389NINDS NIH HHS T32 NS082145U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R21MH113899U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R21MH132078U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01NS112389U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) T32NS082145U.S. Department of Health & Human Services | NIH | National Institute on Deafness and Other Communication Disorders (NIDCD) R01DC018797U.S. Department of Health & Human Services | NIH | National Institute on Deafness and Other Communication Disorders (NIDCD) R01DC019371
Abstract
Spatially heterogeneous synapse loss is a characteristic of many psychiatric and neurological disorders, but the underlying mechanisms are unclear. Here, we show that spatially-restricted complement activation mediates stress-induced heterogeneous microglia activation and synapse loss localized to the upper layers of the medial prefrontal cortex (mPFC) in male mice. Single cell RNA sequencing also reveals a stress-associated microglia state marked by high expression of the apolipoprotein E gene (Apoe
Indexed as
Apolipoproteins EComplement C3Mice, KnockoutMicrogliaPrefrontal CortexStress, PsychologicalSynapsesAnimalsComplement ActivationMaleMemory, Short-TermMiceMice, Inbred C57BLApoe protein, mouseApolipoproteins EC3 protein, mouseComplement C3
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