Evidence map›Paper›PMID 39532758›Full record

ArticleAnnals of surgical oncology2025

Proposal of a Subclassification of pN3 in Squamous Cell Carcinoma of the Penis.

Keval N Patel, Mohit Sharma, Poojitha Yalla, Jebin Aaron, Abhijeet Salunke, Ketul Puj, Vikas Warikoo, Mahendra Pal, Ganesh Bakshi, Shashank J Pandya

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Article in Annals of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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10 authors.

Keval N PatelDepartment of Surgical Oncology, The Gujarat Cancer Research Institute, Ahmedabad, Gujarat, India. drkevalpatel@yahoo.com.ORCID http://orcid.org/0000-0001-7464-0332
Mohit SharmaDepartment of Surgical Oncology, The Gujarat Cancer Research Institute, Ahmedabad, Gujarat, India.
Poojitha YallaDepartment of Surgical Oncology, The Gujarat Cancer Research Institute, Ahmedabad, Gujarat, India.
Jebin AaronDepartment of Surgical Oncology, The Gujarat Cancer Research Institute, Ahmedabad, Gujarat, India.
Abhijeet SalunkeDepartment of Surgical Oncology, The Gujarat Cancer Research Institute, Ahmedabad, Gujarat, India.
Ketul PujDepartment of Surgical Oncology, The Gujarat Cancer Research Institute, Ahmedabad, Gujarat, India.
Vikas WarikooDepartment of Surgical Oncology, The Gujarat Cancer Research Institute, Ahmedabad, Gujarat, India.
Mahendra PalDepartment of Surgical Oncology, The Tata Memorial Hospital, Mumbai, Maharashtra, India.
Ganesh BakshiHinduja Hospital and Research Centre, Mumbai, Maharashtra, India.
Shashank J PandyaDepartment of Surgical Oncology, The Gujarat Cancer Research Institute, Ahmedabad, Gujarat, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the differential prognosis of PLNM as compared to ENE and postulate a sub-classification of the pN3 stage of carcinoma penis.

methodsA retrospective analysis of prospectively maintained data of all the patients of penile squamous cell carcinoma operated at our institute between Jan 2016 and May 2023 was conducted. LASSO Cox regression was used to select variables affecting OS. Cox multivariate analysis was performed to derive significant factors which were permuted to form probable sub-classifications. The best sub-classification was selected based on Akaike Information Criteria (AIC) and Kaplan Meier analysis.

resultsSeventy three patients were included in the study. ENE (HR: 2.6, p = 0.038) and PLNM (HR: 3.3, p = 0.004) were significantly associated with OS on Cox multivariate analysis using LASSO based variable selection. Four probable sub-classifications were created of which pN3a (only ENE) and pN3b (only PLNM and ENE+PLNM) showed least AIC (235.065). The mean OS was 36.6 and 17.2 months respectively for pN3a and pN3b subgroups.

conclusionsENE had a better OS as compared to PLNM and ENE+PLNM in our study. A sub-classification of pN3 stage of TNM classification is proposed. Multi-institutional prospective studies with large number of patients and longer follow-up should validate our findings.

Indexed as

Carcinoma, Squamous CellNeoplasm StagingPenile NeoplasmsAdultAgedFollow-Up StudiesHumansMaleMiddle AgedPrognosisProspective StudiesRetrospective StudiesSurvival Rate

Identifiers

PMID39532758

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