Evidence map›Paper›PMID 39532705›Full record

ArticleThe Journal of organic chemistry2024

Polysubstituted Pyridines from 1,4-Oxazinone Precursors.

L C Thompson, Adrianne M Kinsey, Zannatul Shahla, Jonathan R Scheerer

Abstract read
In one paragraph

Article in The Journal of organic chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

L C ThompsonDepartment of Chemistry, William & Mary, P.O. Box 8795, Williamsburg, Virginia 23187, United States.
Adrianne M KinseyDepartment of Chemistry, William & Mary, P.O. Box 8795, Williamsburg, Virginia 23187, United States.
Zannatul ShahlaDepartment of Chemistry, William & Mary, P.O. Box 8795, Williamsburg, Virginia 23187, United States.
Jonathan R ScheererDepartment of Chemistry, William & Mary, P.O. Box 8795, Williamsburg, Virginia 23187, United States.ORCID 0000-0003-3283-0220

Funding

New methods to prepare 1,4-oxazin-2-ones and applications in the construction of polysubstituted pyridinesR15GM107702 · NIGMS · COLLEGE OF WILLIAM AND MARY · PI SCHEERER, JONATHAN R · 2014 to 2023
$987k
NIGMS NIH HHS R15 GM107702
6 · The paper itself

Abstract

This study describes a general method for the preparation of 1,4-oxazin-2-one intermediates from acetylene dicarboxylate and β-amino alcohol precursors. Oxazinones prepared in this manner were employed in a tandem cycloaddition/cycloreversion reaction sequence with a model alkyne (phenyl acetylene) to give substituted pyridine products. Fundamental reactivity and selectivity studies are complemented by the synthesis of the polycyclic ergot alkaloid natural product xylanigripone A.

Identifiers

PMID39532705
PMCPMC11629385

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.