Evidence map›Paper›PMID 39532581›Full record

ReviewTrends in neurosciences2024

Interconnected neural circuits mediating social reward.

Jennifer Isaac, Malavika Murugan

Abstract readReview
In one paragraph

Review in Trends in neurosciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. IndolethylamineACS chemical neuroscience · 2025
    Article
  5. Organization of Brainwide Inputs to Discrete Lateral Septum Projection Populations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jennifer IsaacNeuroscience Graduate Program, Emory University, Atlanta, GA 30322, USA; Department of Biology, Emory University, Atlanta, GA 30322, USA.
Malavika MuruganNeuroscience Graduate Program, Emory University, Atlanta, GA 30322, USA; Department of Biology, Emory University, Atlanta, GA 30322, USA. Electronic address: mmurug5@emory.edu.

Funding

Medical Scientist Training ProgramT32GM142617 · NIGMS · EMORY UNIVERSITY · PI Jason Yustein · 2022 to 2026
$7.0M
Prefrontal circuits in processing social versus non-social rewardsR01MH130755 · NIMH · EMORY UNIVERSITY · PI Malavika Murugan · 2023 to 2026
$1.5M
Examining the neural substrates of reward in the lateral septumF31MH133373 · NIMH · EMORY UNIVERSITY · PI ISAAC, JENNIFER SAMANTHA · 2023 to 2024
$97k
NIGMS NIH HHS T32 GM142617NIMH NIH HHS F31 MH133373NIMH NIH HHS R01 MH130755
6 · The paper itself

Abstract

Across species, social behaviors are shaped and maintained through positive reinforcement of affiliative social interactions. As with nonsocial rewards, the reinforcing properties of social interactions have been shown to involve interplay between various brain regions and the mesolimbic reward system. In this review, we summarize findings from rodent research on the neural circuits that encode and mediate different components of social reward-seeking behavior. We explore methods to parse and study social reward-related behaviors using available behavioral paradigms. We also compare the neural mechanisms that support social versus nonsocial reward-seeking. Finally, we discuss how internal state and neuromodulatory systems affect reward-seeking behavior and the neural circuits that underlie social reward.

Indexed as

Neural PathwaysRewardSocial BehaviorAnimalsBrainHumansNerve Netaffiliative interactionsinternal statemesolimbic dopamineneuromodulation

Identifiers

PMID39532581
PMCPMC11633286

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.