Evidence map›Paper›PMID 39532541›Full record

ArticleZhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences2024

[Causal relationship between ferroptosis-related gene HSPA5 and hepatocellular carcinoma: a study based on mendelian randomization and mediation analysis].

Bing Cui, Chengcheng Xu, Yuan Xu, Aqin Chen, Chaoming Mao, Yuehua Chen

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. HSPA5 overexpression predicts poor prognosis and drives radioresistance and metastasis in nasopharyngeal carcinoma.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Bing CuiDepartment of Blood Transfusion, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, Jiangsu Province, China. 1000012309@ujs.edu.cn.
Chengcheng XuDepartment of Nuclear Medicine, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, Jiangsu Province, China. 1000012208@ujs.edu.cn.
Yuan XuDepartment of Blood Transfusion, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, Jiangsu Province, China.
Aqin ChenDepartment of Blood Transfusion, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, Jiangsu Province, China.
Chaoming MaoDepartment of Nuclear Medicine, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, Jiangsu Province, China.
Yuehua ChenDepartment of Nuclear Medicine, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, Jiangsu Province, China.

Funding

This work was supported by the Zhenjiang City Guiding Science and Technology Development Program FZ2022084
6 · The paper itself

Abstract

objectivesTo explore a causal relationship between ferroptosis-related gene heat shock protein A5 (HSPA5) and hepatocellular carcinoma (HCC).

methodsA two-sample Mendelian randomization (MR) design was employed to evaluate the causal relationships among HSPA5, regulatory T cells (Tregs), and HCC. Single nucleotide polymorphisms (SNPs) associated with HSPA5, Tregs and HCC were selected as instrumental variables through publicly available genome-wide association studies (GWAS) databases. MR analysis was used to assess the direct effect of HSPA5 on HCC, followed by two-step MR to analyze the potential mediating role of Tregs. Reverse MR analysis was conducted with HCC as the exposure and HSPA5 as the outcome. Inverse variance weighting was the primary method for testing causal associations in all MR analyses. Robustness of the results was confirmed through MR-Egger, weighted median, weighted mode, and simple mode methods. Heterogeneity of instrumental variables was evaluated using Cochrane's

resultsMR analysis showed a positive correlation between elevated HSPA5 expression and HCC risk (all

conclusionsElevated HSPA5 expression is significantly associated with HCC development and poor prognosis. HSPA5 may promote HCC progression by regulating the function of Tregs in the tumor microenvironment.

Indexed as

Carcinoma, HepatocellularEndoplasmic Reticulum Chaperone BiPFerroptosisGenome-Wide Association StudyHeat-Shock ProteinsLiver NeoplasmsMendelian Randomization AnalysisPolymorphism, Single NucleotideHumansT-Lymphocytes, RegulatoryEndoplasmic Reticulum Chaperone BiPHeat-Shock ProteinsHSPA5 protein, humanFerroptosisGenome-wide association studyHeat shock protein A5Hepatocellular carcinomaMendelian randomizationRegulatory T cells

Identifiers

PMID39532541
PMCPMC11736341

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.