ArticleJournal of neurology, neurosurgery, and psychiatry2025
Prevalence of epilepsy: a population-based cohort study in Denmark with comparison to Global Burden of Disease (GBD) prevalence estimates.
Article in Journal of neurology, neurosurgery, and psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed.
- Risk of neurodevelopmental disorders associated with paternal use of valproate during spermatogenesis.Journal of neurology, neurosurgery, and psychiatry · 2026Article
- Mortality attributable to youth drinking in 194 WHO member countries/territories, 1990-2021.Scientific reports · 2026Article
- Working years lost in people with epilepsy according to underlying aetiology: a population-based cohort study.BMJ neurology open · 2026Article
- Forecasting the prevalence of epilepsy in low- and middle-income countries to 2050 using a hybrid deep neural network-transformer modeling framework: insights from the Global Burden of Disease Study 2023.Military Medical Research · 2026Article
- Global, regional, and national children and adolescent epilepsy burden, 1990-2021: an analysis based on the global burden of disease study 2021.Annals of medicine · 2025Article
- Severe Neurological Disorders in the Greenlandic Population: A Nationwide Register-Based Study.Brain and behavior · 2025Article
- Risk of Neurodevelopmental Disorders and Paternal Use of Valproate During Spermatogenesis.JAMA network open · 2025Article
- Prevalence and associated factors of self-reported lifetime epilepsy symptoms in an older population in Russia: the Ural Very Old Study.Frontiers in neurologyArticle
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13 authors.
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Abstract
backgroundThe Global Burden of Disease Study (GBD) produces prevalence estimates for 'idiopathic epilepsy' (ie, of unknown aetiology) and 'secondary epilepsy' (ie, with known aetiology) but does not report prevalence by underlying aetiologies for 'secondary epilepsy'.
methodsWe used nationwide, population-based register data from Denmark to identify underlying causes of epilepsy and their contribution to prevalence of 'secondary epilepsy' and compared with global prevalence data from GBD 2019. We identified all persons with a hospital-based epilepsy diagnosis and a filled prescription for antiseizure medication between 1 January 2009 and 31 December 2018. Epilepsy was categorised into 'idiopathic' or 'secondary' and 'total epilepsy' as the sum of the two epilepsy categories.
resultsOn 31 December 2018, a total of 5 784 284 individuals (49.7% males) were living in Denmark including 40 336 with epilepsy (51.5% males). Perinatal conditions, traumatic brain injury, brain tumours and stroke were prominent underlying causes of 'secondary epilepsy'. The prevalence of 'total epilepsy' in Denmark was 697 (95% CI 691 to 704) per 100 000 population (264 (95% CI 260 to 269) for 'secondary epilepsy' and 433 (95% CI 428 to 438) for 'idiopathic epilepsy'). In the GBD 2019 Study, the prevalence of 'total epilepsy' in 2018 was 682 (95% uncertainty interval (UI) 586 to 784) per 100 000 population (359 (95% UI 324-397) for 'secondary epilepsy' and 324 (95% UI 249 to 404) for 'idiopathic epilepsy').
conclusionsPrevalence estimates of 'total epilepsy', 'idiopathic epilepsy' and 'secondary epilepsy' in Denmark align with the GBD 2019 estimates. In future studies, it is suggested to explicitly include all types of epilepsy, including 'secondary epilepsy', which is currently estimated as sequelae (consequences) of underlying diseases.
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