Evidence map›Paper›PMID 39532348›Full record

ArticleBMJ open2024

Oxygen extraction-guided transfusion strategy in critically ill patients: study protocol for a randomised, open-labelled, controlled trial.

Alberto Fogagnolo, Danila Azzolina, Fabio Silvio Taccone, Emma Pedarzani, Gianluca Pasa, Daniele Marianello, Giorgia Valpiani, Chiara Marchesini, Filippo Annoni, Anthony Moureau and 3 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06102590 (Oxygen Extraction-guided Transfusion Strategy in Critically Ill Patients. A Randomized Controlled Trial.), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06102590 narecruitingnot on this map

Oxygen Extraction-guided Transfusion Strategy in Critically Ill Patients. A Randomized Controlled Trial.

TypeinterventionalSponsorUniversità degli Studi di FerraraRan2023 to 2027Enrolled324ConditionsBlood TransfusionArmsIndividualized red blood cell transfusion strategy, European guidelines red blood cell transfusion strategy
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Alberto FogagnoloUniversity of Ferrara, Ferrara, Italy alberto.fogagnolo@gmail.com.ORCID http://orcid.org/0000-0002-2737-0162
Danila AzzolinaResearch and Innovation Unit, Biostatistics and Clinical Trial Area, University Hospital of Ferrara, Ferrara, Italy.
Fabio Silvio TacconeDepartment of Intensive Care, Université Libre de Bruxelles (ULB), Brussels, Belgium.
Emma PedarzaniResearch and Innovation Unit, Biostatistics and Clinical Trial Area, University Hospital of Ferrara, Ferrara, Italy.
Gianluca PasaDepartment of Medical Science, Surgery and Neurosciences, University of Siena, Siena, Italy.
Daniele MarianelloDepartment of Medical Science, Surgery and Neurosciences, University of Siena, Siena, Italy.
Giorgia ValpianiResearch and Innovation Unit, Biostatistics and Clinical Trial Area, University Hospital of Ferrara, Ferrara, Italy.
Chiara MarchesiniDepartment of translational medicine, University of Ferrrara, Ferrara, Italy.
Filippo AnnoniDepartment of Intensive Care, Université Libre de Bruxelles (ULB), Brussels, Belgium.
Anthony MoureauDepartment of Intensive Care, Université Libre de Bruxelles (ULB), Brussels, Belgium.
Carlo Alberto VoltaUniversity of Ferrara, Ferrara, Italy.
Federico FranchiDepartment of Medical Science, Surgery and Neurosciences, University of Siena, Siena, Italy.
Savino SpadaroDepartment of translational medicine, University of Ferrrara, Ferrara, Italy.ORCID http://orcid.org/0000-0001-5027-5318

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionIn critically ill patients, individualised strategies for red blood cell transfusion (RBCT) are lacking. The objective of this study is to demonstrate the potential advantages of employing an individualised transfusion strategy compared with a restrictive approach, in unselected intensive care unit (ICU) patients.

methodsThis will be a randomised, multicentre, international trial. Two open-label parallel groups will be compared with an allocation ratio of 1:1. The trial is designed to investigate the superiority of the individualised intervention group compared with the standard intervention group. The study will be performed in three mixed, academic ICUs located in two different countries. In the individualised group, prescription of RCBT is restricted to patients who present haemoglobin (Hb) ≤9.0 g/dL and oxygen extraction ratio (O ETHICS AND DISSEMINATION: This trial is approved by the Comitato Etico Area Vasta Centro della Regione Emilia-Romagna (protocol number 350/2023/Sper/AOUFe/PRBCT, date of approval 18/05/2023) and ethic boards at all participating sites. Our results will be published and shared with relevant organisations and healthcare professionals. TRIAL REGISTRATION NUMBER: Clinicaltrials.gov NCT06102590.

Indexed as

Critical IllnessErythrocyte TransfusionIntensive Care UnitsEquivalence Trials as TopicHemoglobinsHumansMulticenter Studies as TopicOxygenRandomized Controlled Trials as TopicHemoglobinsOxygenAcute renal failureBlood bank & transfusion medicineIntensive & critical careRandomized controlled trial

Identifiers

PMID39532348
PMCPMC11575245

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.