Evidence map›Paper›PMID 39532290›Full record

ArticleJournal of child psychology and psychiatry, and allied disciplines2025

Can a warm and supportive adult protect against mental health problems amongst children with experience of adversity? A twin-differences study.

Sarah E Stock, Rebecca E Lacey, Louise Arseneault, Avshalom Caspi, Eloise Crush, Andrea Danese, Rachel M Latham, Terrie E Moffitt, Joanne B Newbury, Jonathan D Schaefer and 2 more

Abstract readTwin Study
In one paragraph

Article in Journal of child psychology and psychiatry, and allied disciplines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sarah E StockResearch Department of Epidemiology and Public Health, University College London, London, UK.ORCID 0000-0002-9517-7970
Rebecca E LaceyResearch Department of Epidemiology and Public Health, University College London, London, UK.
Louise ArseneaultSocial Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID 0000-0002-2938-2191
Avshalom CaspiSocial Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Eloise CrushSocial Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Andrea DaneseSocial Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID 0000-0001-8718-5412
Rachel M LathamSocial Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Terrie E MoffittSocial Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Joanne B NewburyPopulation Health Sciences: Bristol Medical School, University of Bristol, Bristol, UK.
Jonathan D SchaeferInstitute of Child Development, University of Minnesota, Minneapolis, MN, USA.
Helen L FisherSocial Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID 0000-0003-4174-2126
Jessie R BaldwinSocial Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID 0000-0002-5703-5058

Funding

Science CoreP2CHD065563 · NICHD · DUKE UNIVERSITY · PI James Moody · 2015 to 2026
$5.7M
Neuropsychological and genomic signatures of violence exposure in childhoodR01HD077482 · NICHD · DUKE UNIVERSITY · PI CASPI, AVSHALOM · 2013 to 2018
$2.8M
Training in genetic and neurobehavioral mechanisms of addictionT32DA050560 · NIDA · UNIVERSITY OF MINNESOTA · PI Monica Luciana, Scott Ian Vrieze · 2020 to 2026
$2.0M
Economic and Social Research Council ES/P000347/1Economic and Social Research Council ES/S012567/1Eunice Kennedy Shriver National Institute of Child Health and Human Development HD077482Jacobs FoundationMedical Research Council G1002190Medical Research Council MR/X010791/1NICHD NIH HHS P2C HD065563NICHD NIH HHS R01 HD077482NIDA NIH HHS T32 DA050560NIDA NIH HHS T32DA050560Wellcome TrustWellcome Trust 215917/Z/19/ZWellcome Trust 218632/Z/19/Z
6 · The paper itself

Abstract

backgroundAdverse childhood experiences (ACEs) are associated with mental health problems, but many children who experience ACEs do not develop such difficulties. A warm and supportive adult presence in childhood is associated with a lower likelihood of developing mental health problems after exposure to ACEs. However, it is unclear whether this association is causal, as previous research has not accounted for genetic and environmental confounding.

methodsWe used the twin-difference design to strengthen causal inference about whether a warm and supportive adult presence protects children exposed to ACEs from mental health problems. Participants were from the Environmental Risk (E-Risk) Longitudinal Twin Study, a UK population-representative birth cohort of 2,232 same-sex twins. ACEs were measured prospectively from ages 5 to 12. Maternal warmth was assessed at ages 5 and 10 through maternal speech samples. Adult support was assessed through child reports at age 12. Mental health problems were assessed through interviews at age 12 with parents and teachers and participants at age 18.

resultsAmong children exposed to ACEs, those who experienced greater maternal warmth and adult support had lower levels of mental health problems at ages 12 and 18. In monozygotic twin-difference analyses, the protective effects of maternal warmth and adult support on mental health were attenuated by 70% for maternal warmth and 81% for adult support, compared to phenotypic analyses. Twins who experienced greater maternal warmth and adult support had minimal or no difference in mental health compared to their co-twins, concordant for ACE exposure.

conclusionsThe apparent protective effect of a warm, supportive adult against mental health problems following ACEs is largely explained by genetic and environmental confounding. This suggests that interventions which boost maternal warmth and adult support should be supplemented by components addressing wider family environments and heritable vulnerabilities in children exposed to adversity, to improve mental health.

Indexed as

Adverse Childhood ExperiencesMental DisordersMother-Child RelationsSocial SupportAdolescentAdultChildChild, PreschoolFemaleHumansLongitudinal StudiesMaleUnited KingdomACEsadult social supportmaternal warmthProtective factorspsychopathologyresiliencetwin differences

Identifiers

PMID39532290
PMCPMC12018152

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.