ArticleNeurotoxicology2024
The relationship between lead levels and reading acquisition in Spanish speakers, evidence from Uruguayan schoolers.
Article in Neurotoxicology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Lead exposure across early life in Latin America and the Caribbean: prevention strategies and reproductive health considerations.Frontiers in reproductive health · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Lead is a well-known neurotoxicant that continues to affect children´s cognition and behavior. Nevertheless, we still have little evidence on the consequences of lead exposure on reading abilities, particularly in languages other than English.
objectiveTo investigate the cross-sectional association between blood lead levels (BLL), and pre-reading and reading abilities in first-grade children from Montevideo, Uruguay.
methodOf 357 school children (age 67-105 months) enrolled into the study, 287(43 % girls) had a BLL measure and an assessment of pre-reading and reading abilities based on five tests (Verbal comprehension, Sound blending, Letter word identification, Sentence reading fluency, and Passage comprehension) from the Batería III Woodcock-Muñoz. Separate generalized linear models (GLM) were conducted on the relationship between BLL and each test score separately, adjusting for sex, maternal education, household assets, Home Observation for Measurement of the Environment Inventory score, season, test administrator, blood lead testing method, and school clusters.
resultsThe mean BLL was 4.0 ± 2.2 µg/dL, with no differences between the sexes. BLL was associated with a poorer vocabulary knowledge (β [95 % CI]): -0.20 [-0.39, 0.01]. For all the tests, children with BLLs ≥5 µg/dL tended to exhibit poorer performance than children with lower BLLs, but these associations were not statistically significant. When stratified by sex, some evidence of differential associations between BLLs and reading abilities emerged: BLLs were associated with higher phonological awareness in girls (0.32 [0.15, 0.48]) but not boys, and with lower reading comprehension in boys (-0.54 [-1.20, 0.13]) but not girls. Also, lead exposure (BLL ≥ 5 µg/dL) was more strongly and negatively associated with phonological awareness (-1.22 [-1.57, -0.86]) in boys than girls.
conclusionIn this study of first-grade children learning to read in Spanish, we found an inverse association between lead exposure and vocabulary scores, as well as tendency toward lower performance on pre-reading and reading measures among children with BLLs ≥5 µg/dL. Pre-reading and reading abilities are relevant to literacy acquisition; further research is required to confirm these links in larger studies, and to investigate differences between boys and girls, and according to key sociodemographic characteristics.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.