Evidence map›Paper›PMID 39531123›Full record

ReviewEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2025

Meropenem-vaborbactam as intrathecal-sparing therapy for the treatment of carbapenem-resistant K. pneumoniae shunt-related ventriculitis: two case reports and review of the literature.

Gabriele Giuliano, Margherita Sambo, Paola Castellani, Sara Benedetti, Francesca Tarantino, Mario Tumbarello

Abstract readCase ReportsReview
PubMed Publisher
In one paragraph

Review in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Meropenem/vaborbactam activity against carbapenem-resistantFrontiers in cellular and infection microbiology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Gabriele GiulianoDepartment of Medical Biotechnologies, University of Siena, 53100, Siena, Italy. gabriele.giuliano@ao-siena.toscana.it.
Margherita SamboDepartment of Medical Biotechnologies, University of Siena, 53100, Siena, Italy.
Paola CastellaniUnit of Neurosurgical Intensive Care, Azienda Ospedaliera Universitaria Senese, 53100, Siena, Italy.
Sara BenedettiInfectious and Tropical Diseases Unit, Azienda Ospedaliero-Universitaria Senese, Viale Bracci 16, 53100, Siena, Italy.
Francesca TarantinoUnit of Neurosurgical Intensive Care, Azienda Ospedaliera Universitaria Senese, 53100, Siena, Italy.
Mario TumbarelloDepartment of Medical Biotechnologies, University of Siena, 53100, Siena, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recently, an increase in cases of multidrug-resistant Gram-negative bacteria post-neurosurgical ventriculitis and meningitis is reported. Treating these infections has become challenging due to the limited availability of antibiotics and the need to select those with optimal pharmacodynamic and pharmacokinetic profiles. There is limited evidence regarding the use of meropenem-vaborbactam in treating carbapenem-resistant Enterobacterales infections of the central nervous system. We report two new cases of shunt-related ventriculitis due to carbapenem-resistant K.pneumoniae with a favorable microbiological evolution after IV only combination therapy with meropenem-vaborbactam.

Indexed as

Anti-Bacterial AgentsBoronic AcidsCerebral VentriculitisCerebrospinal Fluid ShuntsKlebsiella InfectionsKlebsiella pneumoniaeMeropenemAgedCarbapenemsDrug Therapy, CombinationFemaleHumansMaleMiddle AgedTreatment OutcomeAnti-Bacterial AgentsBoronic AcidsCarbapenemsMeropenemDifficult-to-treat infectionsIntrathecal therapyKPC-K. pneumoniaeMeropenem-vaborbactamShunt-related ventriculitis

Identifiers

PMID39531123

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.