Evidence map›Paper›PMID 39531103›Full record

ArticleJournal of patient-reported outcomes2024

Patient perception of bowel urgency and remission in moderately to severely active Crohn's disease or ulcerative colitis: a qualitative study.

Theresa Hunter Gibble, Larissa Stassek, Gale Harding, Marissa Stefan, Tsion Fikre, Alison Potts Bleakman, Richard Moses, Marla Dubinsky

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Article in Journal of patient-reported outcomes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Theresa Hunter GibbleEli Lilly and Company, 893 S Delaware St., Indianapolis, IN, 46225, USA. hunter_theresa_marie@lilly.com.ORCID 0000-0001-8412-9175
Larissa StassekEvidera, Bethesda, MD, USA.
Gale HardingEvidera, Bethesda, MD, USA.
Marissa StefanEvidera, Bethesda, MD, USA.
Tsion FikreEvidera, Bethesda, MD, USA.
Alison Potts BleakmanEli Lilly and Company, 893 S Delaware St., Indianapolis, IN, 46225, USA.
Richard MosesEli Lilly and Company, 893 S Delaware St., Indianapolis, IN, 46225, USA.
Marla DubinskyIcahn School of Medicine at Mount Sinai, New York, NY, USA.

Funding

Eli Lilly and Company Eli Lilly and Company
6 · The paper itself

Abstract

backgroundBowel urgency, the sudden and immediate need to have a bowel movement, is common in patients with ulcerative colitis (UC) and Crohn's disease (CD). While its impact in UC is well established, less is known about its importance in CD. Further, what level of bowel urgency control patients with UC or CD would consider to be acceptable or in remission has not been established. This qualitative study aimed to understand perceptions of bowel urgency and remission in these patients.

methodsSemi-structured combined concept elicitation and cognitive interviews were conducted to explore how adults with moderate-to-severe UC or CD and current or recent bowel urgency think about the concept of bowel urgency and its remission. The Urgency Numeric Rating Scale (UNRS) was used to examine different levels of bowel urgency severity and to investigate what level of bowel urgency patients would consider as representing remission.

resultsForty adults (n = 19 UC, n = 21 CD) recruited from six US sites completed the study. Sociodemographic and clinical characteristics were similar in both groups. Both groups reported impacts of bowel urgency on physical, social, professional, and emotional aspects of their lives. Most participants (n = 15 UC, n = 18 CD) reported having experienced one or more incidents of urgency-related fecal incontinence. Most participants considered remission to be a state with a normal or reduced number of bowel movements and no or less frequent bowel urgency, and they noted that remission would increase their ability to engage in daily activities without fear of fecal incontinence. Participants were able to map different levels of severity of bowel urgency to UNRS score ranges (scale: 0-10), and they indicated that a mean UNRS score of 5 (UC) or 4 (CD) would be the highest point on the NRS at which they would still consider their bowel urgency to be in remission.

conclusionsBowel urgency is an important issue for patients with either moderate-to-severe UC or CD, and its remission would improve their lives. Further, these patients may still consider bowel urgency to be in remission even at UNRS scores as high as 4 or 5.

Indexed as

Colitis, UlcerativeCrohn DiseaseQualitative ResearchRemission InductionSeverity of Illness IndexAdultAgedDefecationFemaleHumansInterviews as TopicMaleMiddle AgedPerceptionQuality of LifeYoung AdultBowel urgencyCrohn’s diseasePatient-reported outcomeQualitative interviewUlcerative colitisUrgency Numeric Rating Scale

Identifiers

PMID39531103
PMCPMC11557785

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.