Evidence map›Paper›PMID 39531077›Full record

ArticleNeuroradiology2025

Medial temporal atrophy predicts the limbic comorbidities in lewy body disease.

Keita Sakurai, Daita Kaneda, Satoru Morimoto, Yuto Uchida, Shohei Inui, Cong Shang, Yasuyuki Kimura, Chang Cai, Takashi Kato, Kengo Ito and 1 more

Abstract read
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In one paragraph

Article in Neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Practical Brain MRI Guidelines for Anti-Aβ Antibody Treatment in Early Symptomatic Alzheimer's Disease.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Keita SakuraiDepartment of Radiology, National Center for Geriatrics and Gerontology, 7-430 Morioka-Cho, Obu, Aichi, 474-8511, Japan. ksak666@yahoo.co.jp.ORCID http://orcid.org/0000-0002-8849-7335
Daita KanedaChoju Medical Institute, Fukushimura Hospital, Aichi, Japan.
Satoru MorimotoKeio University Regenerative Medicine Research Center, Kanagawa, Japan.
Yuto UchidaDepartment of Neurology, Nagoya City University Graduate School of Medical Sciences, Aichi, Japan.
Shohei InuiDepartment of Radiology, The University of Tokyo, Tokyo, Japan.
Cong ShangDepartment of Radiology, Fujita Health University, Aichi, Japan.
Yasuyuki KimuraDepartment of Clinical and Experimental Neuroimaging, National Center for Geriatrics and Gerontology, Aichi, Japan.
Chang CaiDepartment of Clinical and Experimental Neuroimaging, National Center for Geriatrics and Gerontology, Aichi, Japan.
Takashi KatoDepartment of Radiology, National Center for Geriatrics and Gerontology, 7-430 Morioka-Cho, Obu, Aichi, 474-8511, Japan.
Kengo ItoDepartment of Radiology, National Center for Geriatrics and Gerontology, 7-430 Morioka-Cho, Obu, Aichi, 474-8511, Japan.
Yoshio HashizumeChoju Medical Institute, Fukushimura Hospital, Aichi, Japan.

Funding

Japan Society for the Promotion of Science 16H06277
6 · The paper itself

Abstract

purposeAlthough neuropathological comorbidities, including Alzheimer's disease neuropathological change (AD-NC) and limbic-predominant age-related TAR DNA-binding protein 43encephalopathy neuropathological change (LATE-NC), are associated with medial temporal atrophy in patients with Lewy body disease (LBD), the diagnostic performance of magnetic resonance imaging (MRI)-derived indices remains unclear. This study aimed to investigate the diagnostic performance of MRI-derived indices representing medial temporal atrophy in differentiating between LBD with AD-NC and/or LATE-NC (mixed LBD [mLBD]) and without these comorbidities (pure LBD [pLBD]).

methodsThis study included 24 and 16 patients with pathologically confirmed mLBD and pLBD, respectively. In addition to the well-known medial temporal atrophy and entorhinal cortex atrophy (ERICA) scores, the cross-sectional areas of the bilateral entorhinal cortices/parahippocampal gyri (ABEP) were segmented manually.

resultsEven incorporating various covariates such as age at MRI examination, sex, argyrophilic grain, the MRI-derived indices, especially ABEP, significantly correlated with the severity of AD-NC, and showed a trend of correlation with LATE-NC. For the differentiation between all mLBD and pLBD, the ERICA score and ABEP demonstrated higher diagnostic performance (area under the receiver-operating-characteristic curve [AUC] of 0.80 and 0.87, respectively). Additionally, the highest diagnostic performance for ABEP (AUC, 0.94; sensitivity, 100%; specificity, 88.9%; accuracy, 96%) was observed in differentiating between pLBD and mLBD with two comorbidities (AD-NC and LATE-NC).

conclusionIn patients with pathologically confirmed LBD, medial temporal atrophy was significantly correlated with AD-NC, and showed a trend of correlation with LATE-NC. Moreover, MRI-derived indices indicative of medial temporal atrophy were useful in diagnosing these comorbidities.

Indexed as

Lewy Body DiseaseMagnetic Resonance ImagingTemporal LobeAgedAged, 80 and overAtrophyComorbidityDiagnosis, DifferentialFemaleHumansMaleMiddle AgedSensitivity and SpecificityAlzheimer’s diseaseComorbidityLewy body diseaseLimbic-predominant age-related TDP-43 encephalopathyMagnetic resonance imagingMedial temporal atrophyNeurofibrillary tangle

Identifiers

PMID39531077

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.