Evidence map›Paper›PMID 39531061›Full record

ArticleApplied microbiology and biotechnology2024

Antibacterial mechanism analysis of resveratrol against Salmonella typhimurium via metabolomics.

Na Wang, Cancan Ning, Zheng Zhao, Congyan Yang, Hongtao Ren, Linlin Chen, Qiuying Yu, Gaiping Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Applied microbiology and biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Na Wang *College of Food Science and Technology, Henan Agricultural University, Zhengzhou, 450002, China.
Cancan Ning *College of Food Science and Technology, Henan Agricultural University, Zhengzhou, 450002, China.
Zheng ZhaoCollege of Food Science and Technology, Henan Agricultural University, Zhengzhou, 450002, China.
Congyan YangCollege of Animal Medicine, Henan Agricultural University, Zhengzhou, 450002, China.
Hongtao RenCollege of Food Science and Technology, Henan Agricultural University, Zhengzhou, 450002, China.
Linlin ChenCollege of Food Science and Technology, Henan Agricultural University, Zhengzhou, 450002, China.
Qiuying YuCollege of Food Science and Technology, Henan Agricultural University, Zhengzhou, 450002, China. yuqiuyingzf@163.com.ORCID http://orcid.org/0000-0002-9774-5142
Gaiping ZhangCollege of Animal Medicine, Henan Agricultural University, Zhengzhou, 450002, China.

Funding

Henan modern agricultural industry system 2024the Zhengzhou Key Laboratory of Nutrition and Healthy Food Project KF20190426
6 · The paper itself

Abstract

Salmonella, a common pathogenic bacterium in food, can have a severe impact on food safety and consumer health. At present, Salmonella infection is controlled primarily by the use of antibiotics, which creates unsafe factors for food safety. Thus, finding a natural antibacterial agent is highly practical. In this study, resveratrol was screened from 17 kinds of polyphenols, and its inhibitory mechanism and effects on metabolites of Salmonella typhimurium were investigated to occur through cell wall and membrane damage and metabolomics analysis. The results revealed that the minimum inhibitory concentration of resveratrol against S. typhimurium was 250 μg/mL. After treatment with resveratrol, the lag period of the strain was prolonged, and the cell wall and membrane structure were destroyed. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) further confirmed that resveratrol induced damage to the cell walls and cell membrane. The metabolic profile of S. typhimurium following resveratrol treatment was analysed by gas chromatography‒mass spectrometry. In the metabolome evaluation, we screened 23 differentially abundant metabolites, including 11 upregulated and 12 downregulated metabolites. Eight metabolic pathways of S. typhimurium, including pathways important for amino acid metabolism and the tricarboxylic acid (TCA) cycle, exhibited significant changes after resveratrol treatment. The verification results of the citric acid content, cis-aconitase activity, and ATP content further revealed that the tricarboxylic acid cycle and other related metabolic pathways of S. typhimurium were affected. These results could provide a theoretical possibility for the use of resveratrol as a plant-derived bacteriostatic for food safety problems caused by S. typhimurium. KEY POINTS: • The mechanism of bacteriostasis was studied via metabolomics • Resveratrol causes the death of Salmonella by disrupting the cell wall and membrane.

Indexed as

Anti-Bacterial AgentsMetabolomicsMicrobial Sensitivity TestsResveratrolSalmonella typhimuriumCell MembraneCell WallCitric Acid CycleGas Chromatography-Mass SpectrometryMetabolic Networks and PathwaysMetabolomeMicroscopy, Electron, ScanningMicroscopy, Electron, TransmissionAnti-Bacterial AgentsResveratrolAntibacterial activityMechanismMetabolomicsResveratrolSalmonella typhimurium

Identifiers

PMID39531061
PMCPMC11557638

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.