ArticleAnalytical and bioanalytical chemistry2025
Structural characterization and physicochemical properties of different hydrophilic natural deep eutectic solvents.
Article in Analytical and bioanalytical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- An AI-enhanced evidence-mapping framework for exhaled breathomics in cancer diagnostics: integrating multiple large language models (2005-early 2025).Discover oncology · 2026Article
- Natural deep eutectic solvents as a sustainable alternative for multi-class pesticide extraction in food safety analysis.NPJ science of food · 2026Article
- Green Extraction and Targeted LC-MS Analysis of Biopesticides in Honey Using Natural Deep Eutectic Solvents.Foods (Basel, Switzerland) · 2025Article
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Authors and funding
5 authors.
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Abstract
To overcome the toxic nature of organic solvents, scientific interest in the use of green solvents, particularly natural deep eutectic solvents (NADES), has increased over the past decade, leading to new applications in the food, nutraceutical, pharmaceutical, and cosmetic industries. Understanding the physicochemical properties and molecular interactions of NADES is essential for uncovering new potential applications in these fields. In this study, several lactic and citric acid-based NADES, as well as chloride choline- and urea-based NADES, were evaluated for their physicochemical properties, including density, pH, viscosity, conductivity, and refractive index. Additionally, nuclear magnetic resonance (NMR), and in particular nuclear Overhauser enhancement spectroscopy (NOESY), was employed to investigate the intermolecular interactions between the NADES components to confirm the formation of the eutectic mixture. The extraction efficiency of the confirmed NADES was tested for extracting polyphenols as a proof of concept to highlight their relationship with the measured properties. Lactic and choline chloride-based NADES provided the highest extraction yields. These results were also compared with the predicted extraction capabilities of each NADES provided by the COSMO-RS software.
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