ArticleDiabetologia2025
Prediabetes is associated with elevated risk of clinical outcomes even without progression to diabetes.
Article in Diabetologia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prediabetes and the risk of incident chronic kidney disease in adults: A systematic review and meta-analysis.Biomolecules & biomedicine · 2026Pooled it
- A 4-week community-implemented diabetes prevention program is associated with improved metabolic outcomes at 12 months after participation.Diabetic medicine : a journal of the British Diabetic Association · 2026Trial
- Machine learning prediction of CKD progression in hyperglycemic elderly adults: a prospective community cohort study.Renal failure · 2026Article
- Evaluation of Diabetes Risk Models Applied to the Prediction of Incident Dysglycaemia in African and European Populations.Diabetes, obesity & metabolism · 2026Article
- Nutrient Clusters Associated with the Dietary Inflammatory Index in Patients with Diabetes and Prediabetes: A Prospective Observational Study.Nutrients · 2026Observational
- Should Prediabetes Be Classified as a Treatable Disease?Journal of clinical medicine · 2026Article
- Performance of the Leicester risk assessment and Leicester practice risk scores for assessing the risk of undiagnosed type 2 diabetes or prediabetes in diverse populations: protocol for a systematic review of published validations and updates.Diagnostic and prognostic research · 2026Review
- Associations of Different Definitions of Prediabetes and Diabetes with All-Cause and Cause-Specific Mortality: A Nationally Representative Cohort Study.Military Medical Research · 2026Article
- Five-Year outcomes of a digitally delivered carbohydrate-reduced nutrition intervention for prediabetes: durability of diabetes prevention.Frontiers in nutrition · 2026Article
- Social determinants of health and progression to cardio-renal-metabolic multimorbidity and mortality in people with prediabetes: A prospective cohort study.Diabetes, obesity & metabolism · 2025Observational
- Calcium Signaling and Cardiac Adaptation to Stress: Focus on Pregnancy and Diabetes.Biomolecules · 2025Review
- Ultra-processed food consumption among adults with prediabetes and diabetes, 2001-2018.Diabetes, obesity & metabolism · 2025Article
- Daily low dose aspirin halves incident type 2 diabetes in elderly subjects with prediabetes: a five-year longitudinal cohort study in a real-word population.Cardiovascular diabetology · 2025Observational
- Prognostic impact of prediabetes on long-term cardiovascular outcomes in patients under 35 with premature acute myocardial infarction.Diabetology & metabolic syndrome · 2025Article
- The correlation between the atherogenic index of plasma and the severity of coronary artery disease in acute myocardial infarction patients under different glucose metabolic states.Scientific reports · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
aims/hypothesisPrediabetes (HbA
methodsIn 10,310 participants from the Atherosclerosis Risk in Communities (ARIC) Study (aged 46-70 years, ~55% women, ~20% Black adults) without diabetes at baseline (1990-1992), we used Cox regression to characterise age- and sex-adjusted associations of prediabetes with ~30 year incidence of complications (composite and separately), including atherosclerotic CVD (ASCVD), heart failure, chronic kidney disease (CKD) and all-cause mortality before and after accounting for intervening incidence of diabetes, modelled as a time-varying variable. We calculated the excess risk of complications in prediabetes remaining after accounting for progression to diabetes.
resultsOf the 60% of adults with prediabetes at baseline, ~30% progressed to diabetes (median time to diabetes, 7 years). Over the maximum follow-up of ~30 years, there were 7069 events (1937 ASCVD, 2109 heart failure, 3288 CKD and 4785 deaths). Prediabetes was modestly associated with risk of any complication (HR 1.21 [95% CI 1.15, 1.27]) vs normoglycaemia. This association remained significant after accounting for progression to diabetes (HR 1.18 [95% CI 1.12, 1.24]) with 85% (95% CI 75, 94%) of the excess risk of any complication in prediabetes remaining. Results were similar for the individual complications. CONCLUSIONS/
interpretationProgression to diabetes explained less than one-quarter of the risks of clinical outcomes associated with prediabetes. Prediabetes contributes to the risk of clinical outcomes even without progression to diabetes.
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