Evidence map›Paper›PMID 39530953›Full record

ReviewThe Journal of investigative dermatology2025

Cell Therapy and the Skin: Great Potential but in Need of Optimization.

Sam S Lee, Eddie Gibson Martinez Peña, Aiden A Willis, Chen Chia Wang, Nina Rossa Haddad, Luis A Garza

Abstract readReview
In one paragraph

Review in The Journal of investigative dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sam S LeeDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. Electronic address: slee228@jhmi.edu.
Eddie Gibson Martinez PeñaDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Aiden A WillisDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Chen Chia WangDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Nina Rossa HaddadDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Luis A GarzaDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. Electronic address: LAG@jhmi.edu.

Funding

Injection of autologous volar fibroblasts to the stump site to allow pressure adaptation and enhanced prosthetic use in amputeesUH3AR079376 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI Luis Andres Garza · 2023 to 2026
$2.1M
Mechanism and clinical pilot tst of volar fibroblast to create ectopic volar skinR01AR064297 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI GARZA, LUIS ANDRES · 2013 to 2017
$1.8M
Injection of autologous volar fibroblasts to the stump site to allow pressure adaptation and enhanced prosthetic use in amputeesUG3AR079376 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI GARZA, LUIS ANDRES · 2021 to 2021
$532k
NIAMS NIH HHS R01 AR064297NIAMS NIH HHS UG3 AR079376NIAMS NIH HHS UH3 AR079376
6 · The paper itself

Abstract

Cell therapy is rapidly growing owing to its therapeutic potential for diseases with currently poor outcomes. Cell therapy encompasses both nonengineered and engineered cells and possesses unique abilities such as sense-and-respond functions and long-term engraftment for persistent curative potential. Cell therapy capabilities have expanded to address a wide spectrum of diseases, and our review is focused on dermatological applications. The use of fibroblasts and keratinocytes as cell therapy has shown promise in skin disorders such as epidermolysis bullosa. Future efforts include testing the ability of fibroblasts to reprogram nonvolar to volar skin to reduce stump dermatoses in patients with limb loss using prosthetics.

Indexed as

Cell- and Tissue-Based TherapyFibroblastsKeratinocytesSkin DiseasesAnimalsHumansSkinCell therapyFibroblastsSkin

Identifiers

PMID39530953
PMCPMC12018158

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.