Evidence map›Paper›PMID 39530855›Full record

ReviewEmerging infectious diseases2024

Using SARS-CoV-2 Sequencing Data to Identify Reinfection Cases in the Global Emerging Infections Surveillance Program, United States.

Deanna Muehleman, Bill Gruner, Vivian Hogan, Padraic Fanning, Carol Garrett, Jennifer Meyer, Kelsey Lanter, Sarah Purves, Laurie DeMarcus, Jeffrey Thervil and 4 more

Abstract readReview
In one paragraph

Review in Emerging infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Deanna Muehleman
Bill Gruner
Vivian Hogan
Padraic Fanning
Carol Garrett
Jennifer Meyer
Kelsey Lanter
Sarah Purves
Laurie DeMarcus
Jeffrey Thervil
Bismark Kwaah
Paul Sjoberg
Elizabeth Macias
Anthony Fries

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Centers for Disease Control and Prevention defines SARS-CoV-2 reinfection as a positive COVID-19 test result >90 days after the collection date for the initial positive test or if sequencing confirms a different lineage is causing the reinfection. Reinfection dynamics have been examined by using PCR or antigen surveillance data. We identified patients in the US Military Health System who had >1 positive SARS-CoV-2 test during March 2020-July 2022 by using whole-genome sequencing data to identify reinfection cases, then compared those data with patient demographics, symptoms, and vaccination status. We identified 267 reinfections, of which 90% were caused by the SARS-CoV-2 Omicron variant. Reinfection symptom severity correlated with initial symptom severity and time since first infection. Furthermore, we found intrahost mutation rates varied greatly in 72 cases of continuing infections with the same variant. Continued investigations of reinfections caused by emerging SARS-CoV-2 variants of concern is needed to maintain US military readiness.

Indexed as

COVID-19ReinfectionSARS-CoV-2Whole Genome SequencingAdultCommunicable Diseases, EmergingFemaleGenome, ViralHumansMaleMiddle AgedMilitary PersonnelUnited StatesYoung Adultcoronaviruscoronavirus diseaseCOVID-19public health surveillancereinfectionrespiratory infectionsSARSSARS-CoV-2severe acute respiratory syndrome coronavirus 2United Statesviruseswhole-genome sequencingzoonoses

Identifiers

PMID39530855
PMCPMC11559565

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.