ArticleBrain : a journal of neurology2025
Shared orbitofrontal dynamics to a drug-themed movie track craving and recovery in heroin addiction.
Article in Brain : a journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed.
- Peer-guided movie neurofeedback to facilitate recovery in opioid use disorder.medRxiv : the preprint server for health sciences · 2026Article
- Can the incentive-sensitization theory of addiction incorporate addiction to opioid drugs?Psychopharmacology · 2026Review
- Dynamic Network Reconfiguration of Brain Function During Exposure to Aversive Stimuli.Obesity (Silver Spring, Md.) · 2026Article
- The Impaired Response Inhibition and Salience Attribution Model of Drug Addiction: Recent Neuroimaging Evidence and Future Directions.Annual review of psychology · 2026Review
- Personalizing ecological momentary intervention for substance use disorders through data-driven decision rules.Frontiers in psychiatry · 2026Review
- Continuous Theta Burst Stimulation of the Medial Prefrontal Cortex Reduces Drug Cue Reactivity With a Potential for Improving Outpatient Treatment Outcomes in Cocaine Use Disorder.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Understanding human brain function in real-world environments.PLoS biology · 2025Article
- Uncovering a Timescale Hierarchy by Studying the Brain in a Natural Context.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Movies captivate groups of individuals (the audience), especially if they contain themes of common motivational interest to the group. In drug addiction, a key mechanism is maladaptive motivational salience attribution whereby drug cues outcompete other reinforcers within the same environment or context. We predicted that while watching a drug-themed movie, where cues for drugs and other stimuli share a continuous narrative context, functional MRI responses in individuals with heroin use disorder (iHUD) will preferentially synchronize during drug scenes. Thirty inpatient iHUD (24 male) and 25 healthy controls (16 male) watched a drug-themed movie at baseline and at follow-up after 15 weeks. Results revealed such drug-biased synchronization in the orbitofrontal cortex (OFC), ventromedial and ventrolateral prefrontal cortex, and insula. After 15 weeks during ongoing inpatient treatment, there was a significant reduction in this drug-biased shared response in the OFC, which correlated with a concomitant reduction in dynamically-measured craving, suggesting synchronized OFC responses to a drug-themed movie as a neural marker of craving and recovery in iHUD.
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Registered trials
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