Evidence map›Paper›PMID 39530516›Full record

ArticleThe American journal of gastroenterology2024

Albumin for Spontaneous Bacterial Peritonitis: Care Variation, Disparities, and Outcomes.

Marina Serper, Marya E Pulaski, Siqi Zhang, Tamar H Taddei, David E Kaplan, Nadim Mahmud

Abstract read
In one paragraph

Article in The American journal of gastroenterology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Marina SerperCorporal Michael J. Crescenz VA Medical Center, Philadelphia, Pennsylvania, USA.ORCID 0000-0003-4899-2160
Marya E PulaskiDepartment of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Siqi ZhangCenter for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0009-0009-0610-8809
Tamar H TaddeiDepartment of Medicine, Division of Digestive Diseases, Yale School of Medicine, New Haven, Connecticut, USA.ORCID 0000-0002-6500-1739
David E KaplanCorporal Michael J. Crescenz VA Medical Center, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-3839-336
Nadim MahmudCorporal Michael J. Crescenz VA Medical Center, Philadelphia, Pennsylvania, USA.ORCID 0000-0003-1889-3954

Funding

Cognitive Function, Self-Management, and Health Outcomes among Liver Transplant Recipients: the LivCog CohortR01DK132138 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI Marina Serper · 2022 to 2026
$3.5M
Technology Enabled Strategies to Promote Treatment Adherence in Liver Transplant: The TEST TrialR01DK131547 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI Marina Serper · 2022 to 2026
$3.4M
2/4-American Consortium of Early Liver Transplantation-Prospective Alcohol-associated liver disease Cohort Evaluation (ACCELERATE-PACE)R01AA030963 · NIAAA · UNIVERSITY OF PENNSYLVANIA · PI Marina Serper · 2023 to 2026
$1.6M
Improving Surgical Risk Prediction and Decision Making among Patients with CirrhosisK08DK124577 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI MAHMUD, NADIM · 2021 to 2025
$835k
Understanding Patient Preferences for Surgical Management in the Setting of Cirrhosis: A Mixed-Methods ApproachR03DK134794 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI MAHMUD, NADIM · 2024 to 2025
$244k
National Institute of Diabetes and Digestive and Kidney Diseases, Grifols K08DK124577NIAAA NIH HHS R01 AA030963NIDDK NIH HHS K08 DK124577NIDDK NIH HHS R01 DK131547NIDDK NIH HHS R01 DK132138NIDDK NIH HHS R03 DK134794
6 · The paper itself

Abstract

introductionIntravenous albumin reduces mortality in spontaneous bacterial peritonitis (SBP). We sought to characterize albumin use for SBP over time and investigate patient-level and hospital-level factors associated with use.

methodsA retrospective cohort study in the Veterans Health Administration between 2008 and 2021 evaluated trends and patient-level, practice-level, and facility-level factors associated with use among patients with cirrhosis hospitalized for SBP confirmed with ascitic fluid criteria.

resultsAmong 3,871 veterans with SBP, 803 (20.7%) did not receive albumin, 1,119 (28.9%) received albumin but not per guidelines, and 1,949 (50.3%) received albumin per guidelines; use increased from 66% in 2008 to 88% in 2022. Veterans who identified as Black compared with White were less likely to receive guideline-recommended albumin (Odds ratio [OR] 0.76, 95% confidence interval [CI] 0.59-0.98) in all analyses. Guideline-recommended albumin was more likely to be administered to veterans with Child-Turcotte-Pugh class B (OR 1.39, 95% CI 1.17-1.64) and C (OR 2.21, 95% CI 1.61-3.04) compared with Child-Turcotte-Pugh A; and acute kidney injury Stage 1 (OR 1.48, 95% CI 1.22-1.79), Stage 2 (OR 2.17, 95% CI 1.62-2.91), and Stage 3 (OR 1.68, 95% CI 1.18-2.40) compared with no acute kidney injury. gastroenterology/hepatology consultation (OR 1.60, 95% CI 1.29-1.99), nephrology consultation (OR 1.60, 95% CI 1.23-2.07), and having both gastroenterology/hepatology and nephrology consultations (OR 2.17, 95% CI 1.60-2.96) were associated with higher albumin administration. In exploratory analyses accounting for interactions between model for end-stage liver disease sodium and albumin, guideline-recommended albumin was associated with lower in-hospital mortality (HR 0.90, 95% CI 0.85-0.96). DISCUSSION: Future studies should investigate optimizing albumin use for SBP to reduce the variability and mitigate healthcare disparities.

Indexed as

AlbuminsBacterial InfectionsHealthcare DisparitiesPeritonitisAgedFemaleGuideline AdherenceHumansLiver CirrhosisMaleMiddle AgedPractice Guidelines as TopicPractice Patterns, Physicians'Retrospective StudiesUnited StatesAlbuminsacute kidney injurycirrhosisdecompensationhealth equity

Identifiers

PMID39530516
PMCPMC12066798

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.