ArticleArthritis care & research2025
Occupational and Hobby Exposures Associated With Myositis Phenotypes in a National Myositis Patient Registry.
Article in Arthritis care & research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Infections preceding diagnosis associated with myositis phenotypes in a national patient registry.Clinical and experimental rheumatology · 2025Article
- Article
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Authors and funding
12 authors.
Funding
Abstract
objectiveThe objective of this study was to investigate occupational and hobby exposures to silica, solvents, and heavy metals and the odds of having the idiopathic inflammatory myopathy (IIM) phenotypes dermatomyositis (DM) and polymyositis (PM) versus inclusion body myositis (IBM), lung disease plus fever or arthritis (LD+), and systemic autoimmune rheumatic disease-associated overlap myositis (OM).
methodsThe sample included 1,390 patients (598 with DM, 409 with PM, and 383 with IBM) aged ≥18 years from a national registry. Of these, 218 (16%) were identified with LD+, and 166 (12%) with OM. Of these, 218 (16%) were identified with LD+, and 166 (12%) with OM. We calculated adjusted odds ratios (ORs) and 95% confidence intervals (CIs) and explored joint effects with smoking.
resultsHigh silica exposure was associated with increased odds of having DM (OR 2.02, 95% CI 1.18-3.46, compared to no exposure; P trend = 0.004), LD+ (OR 1.75, 95% CI 1.10-2.78, vs no LD; P trend = 0.005), and OM (OR 2.07, 95% CI 1.19-3.61, P trend = 0.020). Moderate to high heavy metals exposure was associated with greater odds of having LD+ (OR 1.49, 95% CI 1.00-2.14, P trend = 0.026) and OM (OR 1.59, 95% CI 0.99-2.55, P trend = 0.051). Greater odds of having LD+ were seen among smokers with moderate to high silica exposure versus nonsmokers with low or no exposure (high-certainty assessment OR 2.53, 95% CI 1.31-4.90, P interaction = 0.061).
conclusionThese findings, based on a systematic exposure assessment, suggest that occupational and hobby exposures to silica and heavy metals contribute to adult IIM phenotypes, including DM, OM, and LD+, a possible marker for antisynthetase syndrome or other autoantibody-associated lung diseases.
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