Evidence map›Paper›PMID 39530182›Full record

ArticleJournal of cosmetic dermatology2025

E'jiao and Cubilose Formula Induced Antioxidant Activity and Improved Collagen Expression of Human Skin Fibroblasts During Oxidation Damage.

Hang Tie, Xiao Xie, Zichen Zhang, Jianling Zhang, Liang Xu, Haihua Ruan, Tao Wu, Hongyang Zhang

Abstract read
In one paragraph

Article in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hang TieTianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnosis, School of Pharmacy, Tianjin Medical University, Tianjin, People's Republic of China.
Xiao XieNational Engineering Research Center for Gelatin-Based Traditional Chinese Medicine, Liaocheng, Shandong, China.
Zichen ZhangTiangong University, Tianjin Medical College, Tianjin, People's Republic of China.
Jianling ZhangNational Engineering Research Center for Gelatin-Based Traditional Chinese Medicine, Liaocheng, Shandong, China.
Liang XuTianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnosis, School of Pharmacy, Tianjin Medical University, Tianjin, People's Republic of China.
Haihua RuanTianjin Key Laboratory of Food Biotechnology, College of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin, China.
Tao WuTianjin Key Laboratory of Food Biotechnology, College of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin, China.
Hongyang ZhangTianjin Key Laboratory of Food Biotechnology, College of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAs traditional Chinese medicinal materials, E'jiao and cubilose are rich in various bioactive substances with good antioxidant, anti-inflammatory, and immune-regulating effects.

aimTo obtain the optimal ratio of synergistic effect between E'jiao and cubilose.

methodsThe antioxidant capacity of E'jiao and cubilose digestive fluid was evaluated in vitro, as well as the intracellular oxidation balance between HSF cells and 3D whole-skin model induced by H

resultsE'jiao, cubilose, and their different ratios of composites had better scavenging ability against free radicals such as DPPH (2,2-Diphenyl-1-picrylhydrazyl). Using HSF cells induced by H

conclusionsThese findings indicate that the combination of E'jiao and cubilose in a ratio of 2:3 exhibits good synergistic effects, enhancing the ability of cells to resist oxidative damage, promoting cellular renewal and metabolism, and improving skin antiwrinkle capacity.

Indexed as

AntioxidantsCollagenDrugs, Chinese HerbalFibroblastsOxidative StressCells, CulturedDrug SynergismHumansHydrogen PeroxideOxidation-ReductionReactive Oxygen SpeciesSkinSkin AgingAntioxidantsCollagenDrugs, Chinese HerbalHydrogen PeroxideReactive Oxygen Speciesantioxidant activitycubiloseE'jiaooxidation damageskin health

Identifiers

PMID39530182
PMCPMC11743027

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.