Evidence map›Paper›PMID 39530102›Full record

ArticleFrontiers in immunology2024

Delayed macrophage targeting by clodronate liposomes worsens the progression of cytokine storm syndrome.

Kunjan Khanna, Emily Eul, Hui Yan, Roberta Faccio

Abstract read
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kunjan KhannaDepartment of Orthopedics, Washington University in St Louis, St Louis, MO, United States.
Emily EulDepartment of Orthopedics, Washington University in St Louis, St Louis, MO, United States.
Hui YanDepartment of Orthopedics, Washington University in St Louis, St Louis, MO, United States.
Roberta FaccioDepartment of Orthopedics, Washington University in St Louis, St Louis, MO, United States.

Funding

Regulatory Pathways in Osteoclasts and Immune Cells during Inflammatory ArthritisR01AR053628 · NIAMS · WASHINGTON UNIVERSITY · PI FACCIO, ROBERTA · 2006 to 2015
$3.2M
Novel Regulators of Inflammatory Arthritis and Bone ErosionR01AR066551 · NIAMS · WASHINGTON UNIVERSITY · PI FACCIO, ROBERTA · 2015 to 2020
$2.0M
Role of Bone in Primary and Metastatic CancerR01CA235096 · NCI · WASHINGTON UNIVERSITY · PI FACCIO, ROBERTA · 2020 to 2024
$1.8M
Role of Osterix+ Osteolineage Cells in Primary and Metastatic Breast CancerR01CA270030 · NCI · WASHINGTON UNIVERSITY · PI Roberta Faccio · 2023 to 2026
$1.7M
Regulation of hematopoiesis during tumor progressionF31CA284858 · NCI · WASHINGTON UNIVERSITY · PI EUL, EMILY M · 2023 to 2025
$146k
NCI NIH HHS F31 CA284858NCI NIH HHS R01 CA235096NCI NIH HHS R01 CA270030NIAMS NIH HHS R01 AR053628NIAMS NIH HHS R01 AR066551
6 · The paper itself

Abstract

Excessive macrophage activation and production of pro-inflammatory cytokines are hallmarks of the Cytokine Storm Syndrome (CSS), a lethal condition triggered by sepsis, autoimmune disorders, and cancer immunotherapies. While depletion of macrophages at disease onset protects from lethality in an infection-induced CSS murine model, patients are rarely diagnosed early, hence the need to characterize macrophage populations during CSS progression and assess the therapeutic implications of macrophage targeting after disease onset. In this study, we identified MHCII

Indexed as

Clodronic AcidCytokine Release SyndromeLiposomesMacrophagesAnimalsCytokinesDisease Models, AnimalDisease ProgressionMacrophage ActivationMembrane ProteinsMiceMice, Inbred C57BLClodronic AcidCytokinesLiposomesMembrane ProteinsTIM-4 protein, mouseclodronatecytokine storm syndrome (CSS)inflammationmacrophagesTIM4

Identifiers

PMID39530102
PMCPMC11550973

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.