Evidence map›Paper›PMID 39530067›Full record

Observational studyRevista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia2024

The role of HIV as an independent risk factor to cervical HSIL recurrence.

Fernanda Villar Fonseca, Newton Sérgio de Carvalho, Carlos Afonso Maestri, Manuella Fernandes Martins, Dora Pedroso Kowacs

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Fernanda Villar FonsecaUniversidade Positivo CuritibaPR Brazil Universidade Positivo, Curitiba, PR, Brazil.ORCID https://orcid.org/0000-0002-0162-9893
Newton Sérgio de CarvalhoUniversidade Federal do Paraná CuritibaPR Brazil Universidade Federal do Paraná, Curitiba, PR, Brazil.ORCID https://orcid.org/0000-0001-7561-4566
Carlos Afonso MaestriUniversidade Positivo CuritibaPR Brazil Universidade Positivo, Curitiba, PR, Brazil.ORCID https://orcid.org/0000-0003-0200-9802
Manuella Fernandes MartinsUniversidade Positivo CuritibaPR Brazil Universidade Positivo, Curitiba, PR, Brazil.ORCID https://orcid.org/0009-0008-7660-8983
Dora Pedroso KowacsUniversidade Positivo CuritibaPR Brazil Universidade Positivo, Curitiba, PR, Brazil.ORCID https://orcid.org/0000-0002-9903-4731

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To evaluate the role of being human immunodeficiency virus (HIV) positive for predicting the risk of recurrence in women with a cervical high grade squamous intraepithelial lesion (HSIL) diagnosis. Methods: Retrospective observational case-control study, comprising HIV positive (case) and HIV negative (control) women in a 1:4 ratio. Women assisted by the Erasto Gaertner Hospital, between 2009-2018, with cervical HSIL diagnosis, submitted to treatment by Loop electrosurgical excision procedure (LEEP), and with a minimum follow-up of 18 months, were included. The immunological status, number and time to recurrence were analyzed, with p<0.05 considered significant. In a second analysis, only patients with free margins were evaluated. Results: The sample consisted of 320 women (64 cases and 256 controls). Presence of HIV, CD4 levels <200 and detectable viral load (CV) were associated with high risk of recurrence, with odds ratio (OR) of 5.4 (p<0.001/95CI:2.8-10); 3.6 (p<0.001 /IC95:0.6-21.1) and 1.8 (p=0.039 /IC95:0.3-9.3), respectively. In the sample with free margins (n=271), this risk was also higher among seropositive patients, with OR 4.18 (p=0.001/95CI:1.8-9.2). Conclusion: HIV is an independent risk factor for cervical HSIL recurrence and reduced disease-free survival time. Glandular involvement, compromised margins, undetectable CV and CD4<200 also increase the risk of relapse.

Indexed as

HIV InfectionsNeoplasm Recurrence, LocalUterine Cervical NeoplasmsAdultCase-Control StudiesFemaleHumansMiddle AgedRetrospective StudiesRisk FactorsSquamous Intraepithelial Lesions of the CervixDisease-free survivalElectrosurgeryExcision marginsHIV infectionsRecurrenceRisk factorsSquamous intraepithelial lesionsUterine cervical neoplasms

Identifiers

PMID39530067
PMCPMC11554331

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.