Evidence map›Paper›PMID 39529953›Full record

ArticleInnovation (Cambridge (Mass.))2024

Brainstem opioid peptidergic neurons regulate cough reflexes in mice.

Haicheng Lu, Guoqing Chen, Miao Zhao, Huating Gu, Wenxuan Zheng, Xiating Li, Meizhu Huang, Dandan Geng, Minhui Yu, Xuyan Guan and 10 more

Abstract read
In one paragraph

Article in Innovation (Cambridge (Mass.)), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Haicheng LuNational Institute of Biological Sciences, Beijing 102206, China.
Guoqing ChenNational Institute of Biological Sciences, Beijing 102206, China.
Miao ZhaoNational Institute of Biological Sciences, Beijing 102206, China.
Huating GuNational Institute of Biological Sciences, Beijing 102206, China.
Wenxuan ZhengNational Institute of Biological Sciences, Beijing 102206, China.
Xiating LiDepartment of Neurobiology, School of Basic Medical Sciences, Beijing Key Laboratory of Neural Regeneration and Repair, Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing 100069, China.
Meizhu HuangNational Institute of Biological Sciences, Beijing 102206, China.
Dandan GengKey Laboratory of Neural and Vascular Biology, Ministry of Education, Department of Biochemistry and Molecular Biology, Hebei Medical University, Shijiazhuang 050011, China.
Minhui YuNational Institute of Biological Sciences, Beijing 102206, China.
Xuyan GuanNational Institute of Biological Sciences, Beijing 102206, China.
Li ZhangNational Institute of Biological Sciences, Beijing 102206, China.
Huimeng SongDepartment of Neurobiology, School of Basic Medical Sciences, Beijing Key Laboratory of Neural Regeneration and Repair, Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing 100069, China.
Yaning LiKey Laboratory of Neural and Vascular Biology, Ministry of Education, Department of Biochemistry and Molecular Biology, Hebei Medical University, Shijiazhuang 050011, China.
Menghua WuNational Institute of Biological Sciences, Beijing 102206, China.
Fan ZhangKey Laboratory of Neural and Vascular Biology, Ministry of Education, Department of Biochemistry and Molecular Biology, Hebei Medical University, Shijiazhuang 050011, China.
Dapeng LiDepartment of Neurobiology, School of Basic Medical Sciences, Beijing Key Laboratory of Neural Regeneration and Repair, Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing 100069, China.
Qingfeng WuState Key Laboratory of Molecular Development Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.
Congping ShangSchool of Basic Medical Sciences, Guangzhou National Laboratory, Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou 510799, China.
Zhiyong XieDepartment of Psychological Medicine, Zhongshan Hospital, Institute for Translational Brain Research, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200433, China.
Peng CaoNational Institute of Biological Sciences, Beijing 102206, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cough is a vital defensive reflex for expelling harmful substances from the airway. The sensory afferents for the cough reflex have been intensively studied. However, the brain mechanisms underlying the cough reflex remain poorly understood. Here, we developed a paradigm to quantitatively measure cough-like reflexes in mice. Using this paradigm, we found that

Identifiers

PMID39529953
PMCPMC11551472

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.