Evidence map›Paper›PMID 39529940›Full record

ArticleOpen forum infectious diseases2024

From Chaos to Clarity? The Quest for Effective Probiotics in Antibiotic-Associated Diarrhea.

Krishna Rao, Kevin W Garey

Abstract readEditorial
In one paragraph

Article in Open forum infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Krishna RaoUniversity of Michigan Medical School, Ann Arbor, Michigan, USA.ORCID https://orcid.org/0000-0002-9213-7850
Kevin W GareyCollege of Pharmacy, University of Houston, Houston, Texas, USA.

Funding

Diversity Supplement: Decoding the clinical impact of the recent evolution of metronidazole resistance on Clostridium difficile infectionR01AI139261 · NIAID · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI Kevin W Garey, Julian G Hurdle · 2018 to 2026
$6.0M
Data-Driven Interventions for Reducing C. difficile IncidenceR01HS027431 · AHRQ · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RAO, KRISHNA, WIENS, JENNA · 2020 to 2024
$2.4M
AHRQ HHS R01 HS027431NIAID NIH HHS R01 AI139261
6 · The paper itself

Abstract

Antibiotic-associated diarrhea (AAD) frequently complicates treatment of infections. A recent randomized, double-blind, placebo-controlled trial tested a proprietary probiotic mixture and found that it reduced the incidence of AAD by 16%. This is encouraging for patients, but future progress on probiotics for AAD and other conditions depends on transparency around strain selection, probiotic design guided by preclinical mechanistic studies, and rigorously conducted human studies.

Indexed as

antibiotic-associated diarrheaClostridioides difficilelive biopharmaceuticalsprobioticsrandomized controlled trial

Identifiers

PMID39529940
PMCPMC11551611

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.