Evidence map›Paper›PMID 39529876›Full record

ArticleFrontiers in pharmacology2024

Effects of fermented

MingJu Chen, Yuxiao Wu, Hongxuan Yang, Tianfeng Liu, Tongkun Han, Wangqiang Dai, Junyue Cen, Fan Ouyang, Jingjing Chen, Jianxin Liu and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

MingJu Chen *School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, Guangdong, China.
Yuxiao Wu *Guangdong Provincial Key Laboratory of Advanced Drug Delivery, Guangdong Provincial Engineering Center of Topical Precise Drug Delivery System, School of Life Sciences and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou, Guangdong, China.
Hongxuan YangSchool of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, Guangdong, China.
Tianfeng LiuSchool of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, Guangdong, China.
Tongkun HanShenzhen Bao'an District Songgang People's Hospital, Shenzhen, Guangdong, China.
Wangqiang DaiSchool of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, Guangdong, China.
Junyue CenSchool of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, Guangdong, China.
Fan OuyangSchool of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, Guangdong, China.
Jingjing ChenSchool of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, Guangdong, China.
Jianxin LiuSchool of Pharmaceutical Sciences, China-Pakistan International Science and Technology Innovation Cooperation Base for Ethnic Medicine Development in Hunan Province, Hunan University of Medicine, Huaihua, Hunan, China.
Lin ZhouGuangdong Provincial Key Laboratory of Advanced Drug Delivery, Guangdong Provincial Engineering Center of Topical Precise Drug Delivery System, School of Life Sciences and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou, Guangdong, China.
Xuguang HuSchool of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, Guangdong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: This study aimed to establish a fermentation system based on Methods: Untargeted metabolomics was used to analyze differences in metabolites before and after fermentation. Results: LC-AR exhibited stronger antioxidant activity and higher metabolite levels than AR. It also improved liver injury as well as better regulation of lipid levels, pro-inflammatory cytokine levels, and cholesterol-related mRNA. 16S rRNA analysis revealed that LC-AR decreased the Firmicutes/Bacteroidetes ratio, which correlated negatively with triglycerides, total cholesterol, and low-density lipoprotein cholesterol levels. Discussion: These findings suggest that LC-AR may serve as a promising functional food and drug raw material for improving hyperlipidemia, particularly through its beneficial effects on gut microbiota and lipid regulation.

Indexed as

Arctium lappa L. rootfermentedgut microbiotahyperlipidemialactobacilluslipid level

Identifiers

PMID39529876
PMCPMC11551023

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.