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ArticlePlastic and reconstructive surgery. Global open2024

Lymph Node Inclusion in a Modified Osteomyocutaneous Allograft for Vascularized Composite Allotransplantation: Establishment and Feasibility Assessment in a Pig Model.

Stefanie Hirsiger, Ioana Lese, Isabel Arenas Hoyos, Cédric Zubler, David Haberthür, Ruslan Hlushchuk, Valentin Djonov, Yara Banz, Ana Macek, Hendrik von Tengg-Kobligk and 3 more

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Article in Plastic and reconstructive surgery. Global open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

13 authors.

Stefanie HirsigerFrom the Department of Plastic and Hand Surgery, Inselspital University Hospital, University of Bern, Bern, Switzerland.
Ioana LeseFrom the Department of Plastic and Hand Surgery, Inselspital University Hospital, University of Bern, Bern, Switzerland.
Isabel Arenas HoyosFrom the Department of Plastic and Hand Surgery, Inselspital University Hospital, University of Bern, Bern, Switzerland.
Cédric ZublerInstitute of Anatomy, University of Bern, Bern, Switzerland.
David HaberthürInstitute of Anatomy, University of Bern, Bern, Switzerland.
Ruslan HlushchukInstitute of Anatomy, University of Bern, Bern, Switzerland.
Valentin DjonovInstitute of Anatomy, University of Bern, Bern, Switzerland.
Yara BanzInstitute of Pathology, University of Bern, Bern, Switzerland.
Ana MacekDepartment of Diagnostic, Interventional and Paediatric Radiology, Inselspital University Hospital, University of Bern, Bern, Switzerland.
Hendrik von Tengg-KobligkDepartment of Diagnostic, Interventional and Paediatric Radiology, Inselspital University Hospital, University of Bern, Bern, Switzerland.
Daniela CasoniDepartment for BioMedical Research, University of Bern, Bern, Switzerland.
Robert RiebenDepartment for BioMedical Research, University of Bern, Bern, Switzerland.
Radu OlariuFrom the Department of Plastic and Hand Surgery, Inselspital University Hospital, University of Bern, Bern, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Representative translational animal models play a key role in vascularized composite allotransplantation (VCA) research. A composite porcine hindlimb flap, previously described, is a relevant preclinical model. However, its bulkiness and the absence of critical immunologic tissues make it less suitable for investigating the unique immunologic features of VCA. We aimed to further develop this model by reducing its bulkiness and by including donor-draining lymph nodes. Methods: We conducted an anatomic study by harvesting 11 porcine osteomyocutaneous flaps (4 conventional and 7 modified techniques), which were characterized by computed tomography. Furthermore, 8 allotransplantations were performed in Swiss landrace pigs. After the procedure, animals were assigned to a model development and control group (N = 4 per group). No immunosuppression was given, and animals were followed up until grade 3 rejection. Results: With the modified technique, the flap weight was significantly reduced with a mean weight of 831 g, corresponding to 1.8% total body weight versus 1710 g in the conventional technique, representing 4.2% of total body weight ( Conclusions: By modifying the surgical technique, the bulkiness of the flap was markedly reduced, without impairing its vascularization and reliably including vascularized graft-draining lymph nodes. Our modified VCA model in the pig presents distinct advantages for surgery as well as immunologic analysis, warranting a large-scale use for experimental reconstructive transplantation studies.

Identifiers

PMID39529870
PMCPMC11554356

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