Evidence map›Paper›PMID 39529861›Full record

ArticleJournal of oral microbiology2024

Romualdus Nugraha Catur Utomo, Alena Lisa Palkowitz, Lin Gan, Anna Rudzinski, Julia Franzen, Hendrik Ballerstedt, Martin Zimmermann, Lars Mathias Blank, Horst Fischer, Stefan Wolfart and 1 more

Abstract read
In one paragraph

Article in Journal of oral microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Romualdus Nugraha Catur UtomoDepartment of Prosthodontics and Biomaterials, Center of Implantology, RWTH University Hospital Aachen, Aachen, Germany.ORCID https://orcid.org/0000-0001-7512-2377
Alena Lisa PalkowitzDepartment of Dental Materials and Biomaterials Research, RWTH Aachen University Hospital, Aachen, Germany.
Lin GanGenomics Facility, Interdisciplinary Center for Clinical Research (IZKF) RWTH Aachen University Hospital, Aachen, Germany.
Anna RudzinskiGenomics Facility, Interdisciplinary Center for Clinical Research (IZKF) RWTH Aachen University Hospital, Aachen, Germany.
Julia FranzenGenomics Facility, Interdisciplinary Center for Clinical Research (IZKF) RWTH Aachen University Hospital, Aachen, Germany.
Hendrik BallerstedtInstitute of Applied Microbiology-iAMB, Aachen Biology and Biotechnology-ABBt, RWTH Aachen University, Aachen, Germany.
Martin ZimmermannInstitute of Applied Microbiology-iAMB, Aachen Biology and Biotechnology-ABBt, RWTH Aachen University, Aachen, Germany.
Lars Mathias BlankInstitute of Applied Microbiology-iAMB, Aachen Biology and Biotechnology-ABBt, RWTH Aachen University, Aachen, Germany.
Horst FischerDepartment of Dental Materials and Biomaterials Research, RWTH Aachen University Hospital, Aachen, Germany.
Stefan WolfartDepartment of Prosthodontics and Biomaterials, Center of Implantology, RWTH University Hospital Aachen, Aachen, Germany.
Taskin TunaDepartment of Prosthodontics and Biomaterials, Center of Implantology, RWTH University Hospital Aachen, Aachen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Biofilm formation on implant-abutment surfaces can cause inflammatory reactions. Ethical concerns often limit intraoral testing, necessitating preliminary in vitro or animal studies. Here, we propose an in vitro model using human saliva and hypothesize that this model has the potential to closely mimic the dynamics of biofilm formation on implant-abutment material surfaces in vivo. Methods: A saliva stock was mixed with modified Brain-Heart-Infusion medium to form biofilms on Titanium-Aluminum-Vanadium (Ti6Al4V) and Yttria-partially Stabilized Zirconia (Y-TZP) discs in 24-well plates. Biofilm analyses included crystal violet staining, intact cell quantification with BactoBox, 16S rRNA gene analysis, and short-chain fatty acids measurement. As a control, discs were worn in maxillary splints by four subjects for four days to induce in vivo biofilm formation. Results: After four days, biofilms fully covered Ti6Al4V and Y-TZP discs both in vivo and in vitro, with similar cell viability. There was a 60.31% overlap of genera between Conclusion: This

Indexed as

16S rRNA gene analysisbiofilm dynamicscell viabilityHaemophilusNeisseriaPorphyromonasStreptococcusTi6Al4VVeillonellaY-TZP

Identifiers

PMID39529861
PMCPMC11552293

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.