Evidence map›Paper›PMID 39529366›Full record

ArticleSubstance use & misuse2025

Hair Cortisol Concentrations in the Prediction of Early Substance Use Engagement in Youth.

Anastasia Georgiades, Jennifer Godwin, Fernanda C Andrade, William E Copeland, Erin K Davisson, Cynthia M Kuhn, Kaitlyn Burnell, Rick H Hoyle

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Article in Substance use & misuse, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Anastasia GeorgiadesDepartment of Psychology and Neuroscience, Duke University, Durham, NC, USA.ORCID 0000-0003-1937-7601
Jennifer GodwinCenter for Child and Family Policy, Duke University, Box 90545, Durham, NC 27708-0545, USA.ORCID 0000-0001-5258-1351
Fernanda C AndradeDepartment of Psychology and Neuroscience, Duke University, Durham, NC, USA.ORCID 0000-0002-4862-3544
William E CopelandDepartment of Psychology and Neuroscience, Duke University, Durham, NC, USA.ORCID 0000-0002-1348-7781
Erin K DavissonDepartment of Psychology and Neuroscience, Duke University, Durham, NC, USA.ORCID 0000-0002-9061-3948
Cynthia M KuhnDepartment of Psychology and Neuroscience, Duke University, Durham, NC, USA.ORCID 0000-0001-6131-1839
Kaitlyn BurnellDepartment of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0003-0959-6632
Rick H HoyleDepartment of Psychology and Neuroscience, Duke University, Durham, NC, USA.ORCID 0000-0003-0900-2814

Funding

TRANSLATION AND DISSEMINATION COREP30DA023026 · NIDA · DUKE UNIVERSITY · PI HOYLE, RICK · 2008 to 2023
$19.6M
Impact of Lifestyle Disruptions on Problem Drinking in Young AdulthoodF31AA030175 · NIAAA · DUKE UNIVERSITY · PI CHARDULO DIAS DE ANDRADE, FERNANDA · 2022 to 2024
$77k
NIAAA NIH HHS F31 AA030175NIDA NIH HHS P30 DA023026
6 · The paper itself

Abstract

objectiveUnderstanding factors associated with early onset of substance use is critical as using alcohol or drugs at a young age is a strong predictor of later substance dependency. Experiencing stressful life events is associated with increased risk for early substance use in youth. Hair cortisol concentration (HCC) is considered a biomarker of psychological stress experienced over longer periods of time. We examined whether HCC could predict early substance use engagement in youth followed over 5 years.

methodsParticipants were 395 young adolescents (50% female, age range 10-15 years,

resultsHCC did not add to the prediction of early substance use engagement in any of the models, while self-reports of stressful life events and everyday discrimination predicted early substance use engagement in the models comparing 'Early' vs 'Late/No' substance use class membership.

conclusionWe found no evidence of HCC to be associated with early substance use engagement in youth. Nevertheless, our results do confirm that self-reports of stressful everyday life experiences predict earlier substance use engagement, underscoring the role of psychosocial stressors as significant predictors of substance use engagement in youth.

Indexed as

HairHydrocortisoneStress, PsychologicalSubstance-Related DisordersAdolescentChildFemaleHumansLongitudinal StudiesMaleSelf ReportHydrocortisoneEarly substance useHair cortisol concentrationStressYouth

Identifiers

PMID39529366
PMCPMC11718716

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.