Evidence map›Paper›PMID 39529159›Full record

ArticleJournal of orthopaedic surgery and research2024

Histopathological and radiological evaluation of the efficacy of hydroxyapatite-boric acid and hydroxyapatite-magnesium coated Kirschner wires on fracture healing in femoral diaphyseal fractures: an experimental study.

Caglar Tuna Issi, Bilge Kagan Yilmaz, Sadik Kaga, Hasan Huseyin Demirel, Elif Kaga, Mehmet Nuri Konya

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Article in Journal of orthopaedic surgery and research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Caglar Tuna IssiDepartment of Orthopaedic and Traumatology, Ministry of Health Aksaray Training and Research Hospital, Aksaray, Turkey.ORCID http://orcid.org/0000-0003-0737-2678
Bilge Kagan YilmazDepartment of Orthopaedic and Traumatology, Afyonkarahisar Health Science University, Afyonkarahisar, Turkey. kagan.yilmaz@afsu.edu.tr.ORCID http://orcid.org/0000-0002-2765-7833
Sadik KagaDepartment of Biomedical Engineering, Afyon Kocatepe University, Afyonkarahisar, Turkey.ORCID http://orcid.org/0000-0002-6303-7981
Hasan Huseyin DemirelAfyon Kocatepe University Bayat Vocational School, Afyonkarahisar, Turkey.ORCID http://orcid.org/0000-0002-4795-2266
Elif KagaDepartment of Medical Biochemistry, Afyonkarahisar Health Science University, Afyonkarahisar, Turkey.ORCID http://orcid.org/0000-0002-2279-6105
Mehmet Nuri KonyaDepartment of Orthopaedic and Traumatology, Afyonkarahisar Health Science University, Afyonkarahisar, Turkey.ORCID http://orcid.org/0000-0002-5877-8347

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBiomaterials used in fracture healing hold a significant place in orthopedics. This study aimed to develop biomaterials coated with hydroxyapatite (HA), boric acid (BA), and magnesium (Mg) and investigate their effects on fracture healing.

methodsSixty female Wistar Albino rats were included in the study. The subjects were randomized into five groups. Cytotoxicity tests were performed on HA, BA, and Mg, and cell viability rates were calculated. Coatings were applied to Kirschner (K) wires at determined ratios. Group I was the control group with a steel K wire, Group II used HA-coated K wires, Group III used HA + BA-coated K wires, Group IV used HA + BA + Mg-coated K wires, and Group V used HA + Mg-coated K wires. A fracture was induced in the right femur of the subjects, followed by fixation with intramedullary K wires. The subjects were randomly divided into equal numbers and sacrificed at 6 and 12 weeks. Radiological and histopathological evaluations were performed.

resultsIn direct cytotoxicity tests, the highest viability rate was observed in Group IV, while in indirect cytotoxicity tests, it was highest in Group II. In radiological evaluation at the 6th week, the highest scores were in Groups IV and V, while the lowest was in Group III. At the 12th week, the highest scores were in Groups II and V, while the lowest was in Group I. No significant differences were found between the groups (p = 0.837, p = 0.0479). In histopathological evaluation, a significant difference was observed between the groups (p < 0.001), with the highest scores in Group V. A correlation was found between the radiological and histopathological scores (p < 0.001, r = 0.438).

conclusionIt was found that HA + Mg significantly improved histological outcomes in fracture healing. Good histological results can be achieved with the use of Mg-containing implants in both early and late-stage fracture healing. Coating the biomaterials used in fracture fixation with Mg may lead to positive outcomes in fracture healing.

Indexed as

Bone WiresBoric AcidsDurapatiteFemoral FracturesFracture HealingMagnesiumRats, WistarAnimalsCoated Materials, BiocompatibleFemaleRandom AllocationRatsboric acidBoric AcidsCoated Materials, BiocompatibleDurapatiteMagnesiumBiomaterialBoric acidFracture healingHydroxyapatiteMagnesiumNonunion

Identifiers

PMID39529159
PMCPMC11552370

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.