Evidence map›Paper›PMID 39529122›Full record

ArticleJournal of translational medicine2024

Compromised C3b-VSIG4 axis between decidual NK cells and macrophages contributes to recurrent spontaneous abortion.

Siao Chen, Jinghe Zhang, Jian Chen, Jieqi Ke, Yu Huang, Xianghui Du, Binqing Fu, Haiming Wei

Abstract read
In one paragraph

Article in Journal of translational medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Decidual stromal cells drive CD16Frontiers in immunology · 2025
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Siao ChenDepartment of Life Sciences and Medicine, University of Science and Technology of China, 443 Huangshan Road, Hefei, 230027, Anhui, China.
Jinghe ZhangDepartment of Life Sciences and Medicine, University of Science and Technology of China, 443 Huangshan Road, Hefei, 230027, Anhui, China.
Jian ChenDepartment of Life Sciences and Medicine, University of Science and Technology of China, 443 Huangshan Road, Hefei, 230027, Anhui, China.
Jieqi KeDepartment of Life Sciences and Medicine, University of Science and Technology of China, 443 Huangshan Road, Hefei, 230027, Anhui, China.
Yu HuangInstitute of Immunology, University of Science and Technology of China, Hefei, Anhui, China.
Xianghui DuDepartment of Life Sciences and Medicine, University of Science and Technology of China, 443 Huangshan Road, Hefei, 230027, Anhui, China.
Binqing FuDepartment of Life Sciences and Medicine, University of Science and Technology of China, 443 Huangshan Road, Hefei, 230027, Anhui, China. fbq@ustc.edu.cn.
Haiming WeiDepartment of Life Sciences and Medicine, University of Science and Technology of China, 443 Huangshan Road, Hefei, 230027, Anhui, China. ustcwhm@ustc.edu.cn.ORCID 0000-0002-1675-6502

Funding

China Postdoctoral Science Foundation 2022M723037Fundamental Research Funds for the Central Universities WK9100000043Fundamental Research Funds for the Central Universities WK9100000059Innovative Research Group Project of the National Natural Science Foundation of China 32300774Innovative Research Group Project of the National Natural Science Foundation of China 81930037Innovative Research Group Project of the National Natural Science Foundation of China 82201943Key Technologies Research and Development Program 2022YFA1103603
6 · The paper itself

Abstract

NK cells and macrophages constitute the predominant immune cell subsets in the decidua during the first trimester of pregnancy, with macrophages typically adopting an anti-inflammatory phenotype. Conversely, in the third trimester, macrophages undergo a shift towards a pro-inflammatory phenotype concurrent with a reduction in NK cell numbers. The direct regulatory impact of NK cells on macrophage phenotype remains poorly explored. In our investigation, we observed that ICAM1

Indexed as

DeciduaKiller Cells, NaturalMacrophagesAbortion, HabitualFemaleHumansPregnancyComplementDecidual natural killer cellMacrophageRecurrent spontaneous abortionVSIG4

Identifiers

PMID39529122
PMCPMC11556194

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.