ArticleBMC research notes2024
Factors associated with time to relapse in pulmonary tuberculosis patients using penalized Cox models.
Article in BMC research notes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundPulmonary tuberculosis (TB) is a contagious bacterial infection caused by Mycobacterium tuberculosis that primarily affects the lungs. Despite advances in treatment, TB remains a major public health challenge, particularly in developing countries. This retrospective cohort study aimed to identify factors that influence the time to relapse in patients with pulmonary tuberculosis.
methodsAll smear-positive pulmonary tuberculosis patients (1548 patients) whose data were recorded in the tuberculosis registration system of Golestan University of Medical Sciences and Health Services from March 2014 to March 2019, and followed up until February 2021. To analyze the data, we applied LASSO, MCP, and SCAD penalized Cox models.
resultsBased on the AIC and BIC criteria, the MCP penalized model was better than the LASSO and SCAD penalized models. The variables of age at diagnosis (> 35 vs.
conclusionsHealth care systems should focus on identification of factors that influence time to relapse and developing interventions to reduce relapse rates.
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