Evidence map›Paper›PMID 39529048›Full record

ArticleBMC public health2024

Classification of long-term disease patterns in inflammatory bowel disease and analysis of their associations with adverse health events.

Fan Li, Yu Chang, Zhaodi Wang, Zhi Wang, Qi Zhao, Xiaoping Han, Zifeng Xu, Chanjiao Yu, Yue Liu, Shiyu Chang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC public health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Fan Li *The First Hospital of Jilin University, No.1 Xinmin Street, Changchun, 130012, China.
Yu Chang *The First Hospital of Jilin University, No.1 Xinmin Street, Changchun, 130012, China.
Zhaodi WangThe First Hospital of Jilin University, No.1 Xinmin Street, Changchun, 130012, China.
Zhi WangThe First Hospital of Jilin University, No.1 Xinmin Street, Changchun, 130012, China.
Qi ZhaoThe First Hospital of Jilin University, No.1 Xinmin Street, Changchun, 130012, China.
Xiaoping HanThe First Hospital of Jilin University, No.1 Xinmin Street, Changchun, 130012, China.
Zifeng XuThe First Hospital of Jilin University, No.1 Xinmin Street, Changchun, 130012, China.
Chanjiao YuThe First Hospital of Jilin University, No.1 Xinmin Street, Changchun, 130012, China.
Yue LiuThe First Hospital of Jilin University, No.1 Xinmin Street, Changchun, 130012, China.
Shiyu ChangThe First Hospital of Jilin University, No.1 Xinmin Street, Changchun, 130012, China.
Hongyan LiThe First Hospital of Jilin University, No.1 Xinmin Street, Changchun, 130012, China.
Sileng HuThe First Hospital of Jilin University, No.1 Xinmin Street, Changchun, 130012, China.
Yuqin LiThe First Hospital of Jilin University, No.1 Xinmin Street, Changchun, 130012, China. liyuq@jlu.edu.cn.
Tongyu TangThe First Hospital of Jilin University, No.1 Xinmin Street, Changchun, 130012, China. tangty@jlu.edu.cn.

Funding

The Science and Technology Agency Jilin Province grant nos. 20210402013GH and 20200201343JC
6 · The paper itself

Abstract

backgroundWith existing researches identifying an increased rate of long-term conditions (LTCs) among Inflammatory Bowel Disease (IBD) patients, yet there is a lack of exploration into the patterns of comorbidity and prognostic rates for IBD patients with multiple morbidities.

methodsThe study included 8,305 participants who self-reported having IBD, comprising ulcerative colitis (UC) and Crohn's disease (CD). Latent class analysis (LCA) was utilized to create optimal categories of LTC combinations for UC and CD patients with additional long-term conditions. Using Cox proportional hazards models, we compared the all-cause mortality rates over a 16-year follow-up among UC and CD patients within different LTC categories, both without LTCs and with the addition of one LTC, the probability of major adverse cardiovascular events (MACE), and the rates of IBD-related surgeries.

resultsA total of 5,617 participants reported having two or more LTCs, with the LCA method identifying three prevalence categories among CD patients, and four prevalence categories among UC patients. The highest mortality rate among CD patients was found in category 3: (HR 1.789, 95% CI (1.439-2.224)), and the highest rates of MACE were also in category 3: (HR 11.432, 95% CI (9.332-14.005)), with hypertension being the distinguishing characteristic of this category, and the highest rates of IBD-related surgeries being associated with pain in category 1: (HR 1.217, 95% CI (0.983-1.506)). Among UC patients, the highest mortality rate was in category 3: (HR 2.221, 95% CI (1.837-2.684)), with the highest MACE rates found in category 3: (HR 6.422, 95% CI (5.659-7.288)), and the highest rates of IBD-related surgeries being associated with pain, also in category 3: (HR 1.218, 95% CI (1.041-1.425)).

conclusionThe rates of adverse health outcomes in IBD patients is closely associated with multimorbidity patterns, underscoring the need to fully consider multimorbidity patterns in the assessment, management, and treatment strategies for IBD.

Indexed as

Colitis, UlcerativeCrohn DiseaseAdultAgedComorbidityFemaleHumansInflammatory Bowel DiseasesLatent Class AnalysisMaleMiddle AgedProportional Hazards ModelsCrohn diseaseInflammatory bowel diseaseLatent class analysisLong-term conditionsUlcerative colitis

Identifiers

PMID39529048
PMCPMC11552137

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.