Evidence map›Paper›PMID 39528982›Full record

ArticleBMC cancer2024

Multicriteria optimization achieves superior normal tissue sparing in volumetric modulated arc therapy for gastric cancer.

Ling He, Xinrui Gao, Tao Li, Xia Li, Xiaowen Sun, Zhigong Wei, Xingchen Peng, Jianghong Xiao

Abstract read
PubMed Full text at PMC Publisher
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Article in BMC cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Ling He *Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, 610041, China.ORCID http://orcid.org/0000-0001-8224-3740
Xinrui Gao *Radiation Physics Technology Center, Cancer Center, West China Hospital, Sichuan University, Chengdu, 610041, China.
Tao LiRadiation Physics Technology Center, Cancer Center, West China Hospital, Sichuan University, Chengdu, 610041, China.
Xia LiRadiation Physics Technology Center, Cancer Center, West China Hospital, Sichuan University, Chengdu, 610041, China.
Xiaowen SunDepartment of Radiation Oncology, Cancer Center, West China Hospital, Sichuan University, No.37 Guo Xue Xiang, Chengdu, Sichuan, 610041, China.
Zhigong WeiDepartment of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, 610041, China.
Xingchen PengDepartment of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, 610041, China.
Jianghong XiaoRadiation Physics Technology Center, Cancer Center, West China Hospital, Sichuan University, Chengdu, 610041, China. jhx_wch@outlook.com.ORCID http://orcid.org/0000-0002-2514-1614

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the benefits of volumetric modulated arc therapy (VMAT) based on multicriteria optimization (MCO) for gastric cancer patients, particularly the protection of serial organs at risk (OARs) that overlap with the target volume.

methodsMCO and single-criterion optimization (SCO) VMAT plans were conducted among 30 gastric cancer patients, with a prescription dose of 50.4 Gy delivered in 28 fractions. All treatment plans underwent review, and a comparison was made between the active planning time and different dose-volume parameters.

resultsBoth the MCO and SCO VMAT plans achieved the target dose coverage, with no significant difference in the conformity index (CI) for the planning target volume (PTV), at median CI values of 0.887 and 0.891, respectively (P = 0.417). The MCO plans showed a slight but significant increase in the homogeneity index of the PTV, with a median increase of 0.029 (P < 0.001). Additionally, the MCO plans resulted in a lower D

conclusionsMCO can effectively help the physicians to quickly select an optimal treatment plan for patients with gastric cancer. It has been shown that MCO VMAT plans can significantly reduce the dose to OARs and shorten the active planning time, with acceptable target coverage. In addition, these plans take less dosimetric time, thereby streamlining the treatment planning process.

Indexed as

Organs at RiskRadiotherapy DosageRadiotherapy, Intensity-ModulatedRadiotherapy Planning, Computer-AssistedStomach NeoplasmsAgedFemaleHumansMaleMiddle AgedOrgan Sparing TreatmentsGastric cancerMulti-criteria optimizationRadiotherapy planningSerial organSingle-criteria optimizationVolumetric modulated arc therapy

Identifiers

PMID39528982
PMCPMC11552167

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.