Evidence map›Paper›PMID 39528968›Full record

ArticleBMC infectious diseases2024

Design, creation, and use of the Test Us Bank (TUB) COVID-19 sample biorepository.

John Broach, Chad Achenbach, Stephanie Behar, Laurel O'Connor, Seanan Tarrant, Julia Ferranto, Colton Wright, Paul Hartin, Taylor Orwig, Janvi Nanavati and 41 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

51 authors.

John BroachDepartment of Emergency Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA. john.broach@umassmemorial.org.
Chad AchenbachDivision of Infectious Diseases, Department of Medicine, Havey Institute for Global Health, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, 94305, USA.
Stephanie BeharProgram in Digital Medicine, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Laurel O'ConnorDepartment of Emergency Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Seanan TarrantProgram in Digital Medicine, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Julia FerrantoProgram in Digital Medicine, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Colton WrightProgram in Digital Medicine, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Paul HartinProgram in Digital Medicine, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Taylor OrwigProgram in Digital Medicine, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Janvi NanavatiCenter for Clinical and Translational Science, University of Massachusetts, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Benedict KalibalaCenter for Clinical and Translational Science, University of Massachusetts, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Kelsey WoodsCenter for Clinical and Translational Science, University of Massachusetts, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Bernadette ShawCenter for Clinical and Translational Science, University of Massachusetts, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Julie FlahiveDepartment of Population and Quantitative Health Sciences, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Bruce BartonDepartment of Population and Quantitative Health Sciences, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Nathaniel HaferCenter for Clinical and Translational Science, University of Massachusetts, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Carly HerbertProgram in Digital Medicine, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Nisha FaheyProgram in Digital Medicine, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Laura GibsonDivision of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Karl SiminDepartment of Molecular, Cell, and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Timothy KowalikDepartment of Microbiology and Physiological Systems, UMass Chan Medical School, Worcester, MA, USA.
Doyle V WardDepartment of Microbiology and Physiological Systems, UMass Chan Medical School, Worcester, MA, USA.
Agha W MirzaDivision of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Robert L MurphyDivision of Infectious Diseases, Department of Medicine, Havey Institute for Global Health, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, 94305, USA.
Matthew CaputoDivision of Infectious Diseases, Department of Medicine, Havey Institute for Global Health, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, 94305, USA.
Bryan BuchholzDepartment of Biomedical Engineering, University of Massachusetts Lowell, Lowell, MA, USA.
Heidi FantasiaSusan and Alan Solomont School of Nursing, University of Massachusetts Lowell, Lowell, MA, USA.
Ainat KorenSusan and Alan Solomont School of Nursing, University of Massachusetts Lowell, Lowell, MA, USA.
Lisa MarchandSusan and Alan Solomont School of Nursing, University of Massachusetts Lowell, Lowell, MA, USA.
Simisola OludareGeorgia Arrhythmia Consultants and Research Institute, Macon, GA, USA.
Felix SogadeGeorgia Arrhythmia Consultants and Research Institute, Macon, GA, USA.
Dana RitlandUrban Family Practice, PC, Marietta, GA, USA.
Cedrice DavisUrban Family Practice, PC, Marietta, GA, USA.
Allen GrenierDepartment of Family Medicine and Community Health, University of Kansas Medical Center, Kansas, KA, USA.
Christi BaronDepartment of Family Medicine and Community Health, University of Kansas Medical Center, Kansas, KA, USA.
Ellie BrentDepartment of Family Medicine and Community Health, University of Kansas Medical Center, Kansas, KA, USA.
Jennifer Bacani McKenneyFredonia Family Care, Fredonia, KA, USA.
Nancy ElderOregon Rural Practice-based Research Network, Oregon Health and Science University, Portland, OR, USA.
LeAnn MichaelsOregon Rural Practice-based Research Network, Oregon Health and Science University, Portland, OR, USA.
Laura FerraraOregon Rural Practice-based Research Network, Oregon Health and Science University, Portland, OR, USA.
Grant TheronDSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Stellenbosch University, Cape Town, MA, South Africa.
Zaida PalmerDSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Stellenbosch University, Cape Town, MA, South Africa.
Barcey LevyDepartment of Family Medicine, University of Massachusetts Chan Medical School, Iowa, IA, USA.
Jeanette DalyDepartment of Family Medicine, University of Massachusetts Chan Medical School, Iowa, IA, USA.
Kim ParangDepartment of Family Medicine, University of Massachusetts Chan Medical School, Iowa, IA, USA.
Megan SchmidtDepartment of Community and Behavioral Health, College of Public Health, University of Iowa, Iowa, IA, USA.
Denis BuxtonNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MA, USA.
William HeetderksDepartment of Emergency Medicine, National Heart, Lung, and Blood institute, NIH, via contract with Guidehousel, Bethesd, MD, USA.
Yukari C ManabeDivision of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Apurv SoniProgram in Digital Medicine, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
David McManusProgram in Digital Medicine, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.

Funding

University of Massachusetts Center for Clinical and Translational ScienceKL2TR001455 · NCATS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI KIEFE, CATARINA I. · 2015 to 2024
$5.0M
NCATS NIH HHS KL2 TR001455
6 · The paper itself

Abstract

Shortly after the first case of SARS-CoV-2 was diagnosed a public health emergency (PHE) was declared and a multi-agency response was initiated within the US federal government to create and propagate testing capacity. As part of this response, an unprecedented program designated Rapid Acceleration of Diagnostics (RADx) Tech was established by the National Institutes of Health (NIH) to facilitate the development of point-of-care tests for the COVID-19. The RADx Tech Clinical Studies Core (CSC), located at the University of Massachusetts Chan Medical School (UMass Chan), with partnering academic, private, and non-governmental organizations around the country, was tasked with developing clinical studies to support this work. This manuscript details development of a biorepository specifically focused on the collection and storage of samples designed for diagnostic platform development. It highlights the unified collection and annotation process that enabled gathering a diverse set of samples. This diversity encompasses the geography and backgrounds of the participants as well as sample characteristics such as variant type and RT-PCR cycle threshold (CT) value of the corresponding reference sample on a uniform clinical reference platform.

Indexed as

Biological Specimen BanksCOVID-19SARS-CoV-2Specimen HandlingCOVID-19 TestingHumansNational Institutes of Health (U.S.)Point-of-Care TestingUnited States

Identifiers

PMID39528968
PMCPMC11556042

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.