Evidence map›Paper›PMID 39528964›Full record

ArticleBMC genomics2024

Comparative ultrastructural and transcriptomic profile analysis of skin tissues from indigenous, improved meat, and dairy goat breeds.

Xiling Hou, Xianwei Wang, Shuang Hou, Jiangyang Dang, Xinyu Zhang, Jianxiang Tang, Yinghua Shi, Sen Ma, Zejun Xu

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC genomics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Xiling Hou *College of Animal Science and Technology, Henan Agricultural University, Zhengzhou, Henan, 450002, China.
Xianwei Wang *Henan Provincial Animal Husbandry General Station, Zhengzhou, Henan, 450002, China.
Shuang HouCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou, Henan, 450002, China.
Jiangyang DangCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou, Henan, 450002, China.
Xinyu ZhangCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou, Henan, 450002, China.
Jianxiang TangCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou, Henan, 450002, China.
Yinghua ShiCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou, Henan, 450002, China.
Sen MaCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou, Henan, 450002, China. ms0321021@163.com.
Zejun XuHenan Provincial Animal Husbandry General Station, Zhengzhou, Henan, 450002, China. xuzejun1966@163.com.

Funding

National Natural Science Foundation of China 31872332the Modern Agricultural production system of Henan meat goat and sheep HARS-22-15-Z1the Science and Innovation training program for college students in the College of Animal Science and Technology of HAU DK202201
6 · The paper itself

Abstract

backgroundHigh-quality goatskins are valuable byproducts usually produced by indigenous goat breeds with poorer production performance in Asia and Africa. However, the genetic and molecular mechanisms underpinning goatskin's biomechanical properties (e.g., tensile strength) remain elusive. Mechanistic exploration of these traits could greatly aid the genetic improvement and genetic resource conservation of native breeds in these regions. To fulfill this purpose, we collected skin tissues from three goat breeds: Huai goat (HG), a Chinese native variety producing high-quality goatskins; Yudong meat goat (YDMG), a crossbreed of HG and Boer goat; Henan dairy goat (HNDG), a dairy goat breed.

resultsScanning electronic microscopy analysis of skin tissues found that the collagen fiber diameters, collagen fibril diameters, and crimps significantly differed among the three goat breeds; however, collagen fibril diameters are similar in HG and HNDG. A sum of 230, 775, and 86 differentially expressed genes (DEGs) were identified from YDMG versus HNDG, HG versus HNDG, and YDMG versus HG, respectively. Functional enrichment analysis suggested that signaling pathways involved in fatty acid, retinol, steroid metabolisms, and GO items related to the physical properties of the skin (e.g., collagen-containing extracellular matrix) are significantly overrepresented in DEGs identified from meat versus dairy goats. Furthermore, 106 DEGs (e.g., COL1A1, COL1A2, and SPARC) showed specific expression patterns in HG and YDMG versus HNDG. Items about biophysical features of skin (e.g., extracellular matrix organization and ECM proteoglycans) are markedly enriched. Protein-protein interaction analysis suggested that two growth factors (IGF1 and PDGFD) are latent collagen and other ECM protein expression modulators.

conclusionUltrastructural analysis of goat skin tissues suggested that collagen fibril diameter is not a major factor affecting goatskin quality. Transcriptomic profiles unveiled core genes and associated biological processes potentially involved in regulating goatskin quality. These discoveries shined new light on deeper understanding the mechanisms of hide-related traits in goat and other livestock.

Indexed as

Gene Expression ProfilingGoatsSkinAnimalsBreedingMeatTranscriptomeBiomechanical propertyCollagen fibril diameterECM organizationGoatskin qualityHormonesIGF1

Identifiers

PMID39528964
PMCPMC11556019

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