Evidence map›Paper›PMID 39528945›Full record

ArticleBMC gastroenterology2024

Impact of sociodemographic disparities on sarcopenia, telomere length, and mortality in patients with liver disease in the US population.

Camille A Kezer, Victoria Kusztos, Blake Kassmeyer, Ryan Lennon, Puru Rattan, Patrick S Kamath, Vijay H Shah, Douglas A Simonetto

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC gastroenterology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Camille A KezerDivision of Gastroenterology and Hepatology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. kezer.camille@mayo.edu.
Victoria KusztosDepartment of Internal Medicine, Mayo Clinic, Rochester, MN, USA.
Blake KassmeyerDepartment of Statistics, Mayo Clinic, Rochester, MN, USA.
Ryan LennonDepartment of Statistics, Mayo Clinic, Rochester, MN, USA.
Puru RattanDivision of Gastroenterology and Hepatology, University of Pennsylvania, Philadelphia, PA, USA.
Patrick S KamathDivision of Gastroenterology and Hepatology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
Vijay H ShahDivision of Gastroenterology and Hepatology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
Douglas A SimonettoDivision of Gastroenterology and Hepatology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.

Funding

UNIVERSITY OF PENNSYLVANIA TRAINING IN GASTROENTEROLOGYT32DK007066 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI JONATHAN P KATZ · 1986 to 2026
$11.7M
NIDDK NIH HHS T32 DK007066
6 · The paper itself

Abstract

BACKGROUND &

aimsSarcopenia is common in patients with liver disease and both sarcopenia and short telomeres are associated with mortality, however their relationship in patients with liver disease remains unknown.

methodsA cohort of 16,072 adults from the National Health and Nutrition Examination Survey from 1999 to 2006 was analyzed. Liver disease was defined by aminotransferases and classified into etiology-based categories. Sarcopenia was defined by dual-energy x-ray absorptiometry. All analyses were conducted separately on each multiple imputation data set and combined via Rubin's rules. P-values for group comparisons were calculated by testing logistic regression parameter estimates. Cox proportional hazards regression was used for mortality analysis with mortality data available until 2015.

resultsSarcopenia was present in 9.5% of patients with liver disease. Age, race, income, education, physical inactivity, and certain medical comorbidities were associated with sarcopenia. Patients with liver disease and sarcopenia had significantly shorter telomeres than patients with liver disease without sarcopenia when unadjusted for age. The interaction between telomere length and sarcopenia was significantly associated with all-cause mortality.

conclusionsThe implications of telomere length on all-cause mortality in patients with liver disease varied by age and sarcopenia status. Shorter telomeres appear to be more highly associated with increased mortality in older patients without sarcopenia.

Indexed as

Liver DiseasesNutrition SurveysSarcopeniaAdultAgedAge FactorsComorbidityFemaleHumansMaleMiddle AgedProportional Hazards ModelsSociodemographic FactorsSocioeconomic FactorsTelomereTelomere ShorteningChronic liver diseaseMortalityNHANESSarcopeniaTelomeres

Identifiers

PMID39528945
PMCPMC11555844

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.