Evidence map›Paper›PMID 39528902›Full record

ReviewMolecular diversity2025

Insight on novel sulfamoylphenyl pyrazole derivatives as anticancer carbonic anhydrase inhibitors.

Rehab F Ahmed, Walaa R Mahmoud, Nagwa M Abdelgawad, Amany Belal, Reem I Alsantali, Mona F Said

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecular diversity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rehab F AhmedPharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini St., Cairo, 11562, Egypt. rehab.abdelmoneim@pharma.cu.edu.eg.
Walaa R MahmoudPharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini St., Cairo, 11562, Egypt.
Nagwa M AbdelgawadPharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini St., Cairo, 11562, Egypt.
Amany BelalDepartment of Pharmaceutical Chemistry, College of Pharmacy, Taif University, P.O.Box 11099, 21944, Taif, Saudi Arabia.
Reem I AlsantaliDepartment of Pharmaceutical Chemistry, College of Pharmacy, Taif University, P.O.Box 11099, 21944, Taif, Saudi Arabia.
Mona F SaidPharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini St., Cairo, 11562, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As another part continue for our previous study, variable substituted pyrazoles bearing sulfamoylphenyl moiety were synthesized and screened against two cancer related human carbonic anhydrase (hCA) isoforms and acetazolamide (AAZ) used as a reference standard. Some compounds as 4e and 6c manifested a promising inhibitory activity against both isoforms (K

Indexed as

Antineoplastic AgentsCarbonic Anhydrase InhibitorsPyrazolesApoptosisCarbonic AnhydrasesCell Line, TumorCell ProliferationDrug Screening Assays, AntitumorHumansMCF-7 CellsMolecular Docking SimulationStructure-Activity RelationshipAntineoplastic AgentsCarbonic Anhydrase InhibitorsCarbonic AnhydrasesPyrazolesAcetazolamideCarbonic anhydrase inhibitionMolecular modellingSulfamoylphenyl

Identifiers

PMID39528902
PMCPMC12454493

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.