Evidence map›Paper›PMID 39528900›Full record

ArticleEJNMMI physics2024

Partial volume correction for Lu-177-PSMA SPECT.

Yibin Liu, Zhonglin Lu, Gefei Chen, Kuangyu Shi, Greta S P Mok

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EJNMMI physics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Quantitative SPECT/CT: Technique and Clinical Applications.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026
    Review
  11. MIRD Pamphlet No. 33: MIRDpvc-A Software Tool for Recovery Coefficient-Based Partial-Volume Correction.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yibin LiuDepartment of Electrical and Computer Engineering, Biomedical Imaging Laboratory (BIG), Faculty of Science and Technology, University of Macau, Avenida da Universidade, Taipa, Macau SAR, China.
Zhonglin LuDepartment of Electrical and Computer Engineering, Biomedical Imaging Laboratory (BIG), Faculty of Science and Technology, University of Macau, Avenida da Universidade, Taipa, Macau SAR, China.
Gefei ChenDepartment of Electrical and Computer Engineering, Biomedical Imaging Laboratory (BIG), Faculty of Science and Technology, University of Macau, Avenida da Universidade, Taipa, Macau SAR, China.
Kuangyu ShiDepartment of Nuclear Medicine, Bern University Hospital, Inselspital, University of Bern, Freiburgstr. 18, Bern, 3010, Switzerland. kuangyu.shi@dbmr.unibe.ch.
Greta S P MokDepartment of Electrical and Computer Engineering, Biomedical Imaging Laboratory (BIG), Faculty of Science and Technology, University of Macau, Avenida da Universidade, Taipa, Macau SAR, China. gretamok@um.edu.mo.ORCID http://orcid.org/0000-0002-2962-2087

Funding

Fundo para o Desenvolvimento das Ciências e da Tecnologia FDCT 0099/2021/AFundo para o Desenvolvimento das Ciências e da Tecnologia FDCT 0178/2024/AMJ
6 · The paper itself

Abstract

backgroundThe limited spatial resolution in SPECT images leads to partial volume effect (PVE), degrading the subsequent dosimetric accuracy. We aim to quantitatively evaluate PVE and partial volume corrections (PVC), i.e., recovery coefficient (RC)-PVC (RC-PVC), reblurred Van-Cittert (RVC) and iterative Yang (IY), in

methodsWe employed a geometrical cylindrical phantom containing five spheres (diameters ranging from 20 to 40 mm) and 40 XCAT phantoms with various anatomical variations and activity distributions. SIMIND Monte Carlo code was used to generate realistic noisy projections. In the clinical study, sequential quantitative SPECT/CT imaging at 4 time-points post

resultsIn the simulation study, the spheres experienced significant PVE, i.e., 0.26 RC and 0.70 RC for the 20 mm and 40 mm spheres, respectively. RVC and IY improved the RC of the 20 mm sphere to 0.37 and 0.75 and RC of the 40 mm sphere to 0.96 and 1.04. Mismatch in mask increased the activity error for all spheres in IY. RVC increased noise and caused Gibbs ringing artifacts. For XCAT phantoms, both RVC and IY performed comparably and were superior to RC-PVC in reducing the MAE of the kidneys. However, IY and RC-PVC outperformed RVC for tumors. The XCAT phantom study and clinical study showed a similar trend in the kidney and tumor activity differences between non-PVC and PVC.

conclusionsPVE greatly impacts activity quantification, especially for small objects. All PVC methods improve the quantification accuracy in

Indexed as

177Lu-PSMA-617Iterative YangPartial volume correctionReblurred Van-CittertRecovery coefficientSPECT/CT

Identifiers

PMID39528900
PMCPMC11555037

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.