Evidence map›Paper›PMID 39528844›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2025

Towards the clinical translation of a silver sulfide nanoparticle contrast agent: large scale production with a highly parallelized microfluidic chip.

Katherine J Mossburg, Sarah J Shepherd, Diego Barragan, Nathaniel H O, Emily K Berkow, Portia S N Maidment, Derick N Rosario Berrios, Jessica C Hsu, Michael J Siedlik, Sagar Yadavali and 3 more

Abstract read
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Katherine J Mossburg *Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.
Sarah J Shepherd *Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.
Diego BarraganDepartment of Radiology, University of Pennsylvania, Philadelphia, PA, USA.
Nathaniel H ODepartment of Radiology, University of Pennsylvania, Philadelphia, PA, USA.
Emily K BerkowDepartment of Radiology, University of Pennsylvania, Philadelphia, PA, USA.
Portia S N MaidmentDepartment of Radiology, University of Pennsylvania, Philadelphia, PA, USA.
Derick N Rosario BerriosDepartment of Radiology, University of Pennsylvania, Philadelphia, PA, USA.
Jessica C HsuDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.
Michael J SiedlikInfiniFluidics, Inc, Philadelphia, PA, USA.
Sagar YadavaliInfiniFluidics, Inc, Philadelphia, PA, USA.
Michael J MitchellDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.
David IssadoreDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA. issadore@seas.upenn.edu.
David P CormodeDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA. david.cormode@pennmedicine.upenn.edu.ORCID 0000-0002-8391-9500

Funding

SUMMER UNDERGRADUATE PROGRAM TO EDUCATE RADIATION SCIENTISTS (SUPERS)R25CA140116 · NCI · UNIVERSITY OF PENNSYLVANIA · PI JAY FITZGERALD DORSEY · 2010 to 2026
$4.1M
Nanoparticle contrast agents for earlier breast cancer detectionR01CA227142 · NCI · UNIVERSITY OF PENNSYLVANIA · PI CORMODE, DAVID PETER · 2018 to 2022
$2.5M
CT imaging and therapy of inflammatory bowel disease via catalytic ceria nanoparticlesF31EB034165 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI ROSARIO, DERICK · 2022 to 2023
$94k
National Nanotechnology Initiative NNCI-2025608NCI NIH HHS R01 CA227142NCI NIH HHS R25 CA140116NIBIB NIH HHS F31 EB034165NIBIB NIH HHS F31-EB034165
6 · The paper itself

Abstract

purposeUltrasmall silver sulfide nanoparticles (Ag

methodsWe herein report the use of a scalable silicon microfluidic system (SSMS) for the large-scale synthesis of Ag

resultsUsing SSMS chips with 1 channel, 10 parallelized channels, and 256 parallelized channels, we determined that the Ag

conclusionsThese studies have identified a promising method for the large-scale production of Ag

Indexed as

Contrast MediaLab-On-A-Chip DevicesMicrofluidic Analytical TechniquesNanoparticlesSilver CompoundsAnimalsFemaleMiceContrast MediaSilver Compoundssilver sulfideContrast agentsHigh throughputLarge scale synthesisNanoparticlesSilver sulfide

Identifiers

PMID39528844
PMCPMC11753937

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.