Evidence map›Paper›PMID 39528836›Full record

SynthesisNeurosurgical review2024

Evaluating efficacy and safety of laser interstitial thermal therapy in patients with newly diagnosed and recurrent glioblastoma: a systematic review and meta-analysis.

Hussain Sohail Rangwala, Muhammad Ashir Shafique, Muhammad Saqlain Mustafa, Ritesh Kumar, Janta Devi, Burhanuddin Sohail Rangwala, Syed Muhammad Sinaan Ali, Adarsh Raja, Javed Iqbal, Mirha Ali and 1 more

Registry-linked trialAbstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Neurosurgical review, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07616986 (Laser Interstitial Thermal Therapy for Ultra-Early, Pre-Radiotherapy Glioblastoma Recurrence), which is not on this map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07616986 narecruitingnot on this mapstarted 2026, after this paper: background citation

Laser Interstitial Thermal Therapy for Ultra-Early, Pre-Radiotherapy Glioblastoma Recurrence

TypeinterventionalSponsorInsel Gruppe AG, University Hospital BernRan2026 to 2028Enrolled12ConditionsGlioblastoma (GBM), Glioblastoma - CategoryArmsLITT
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hussain Sohail RangwalaDepartment of Medicine, Jinnah Sindh Medical University, Karachi, Pakistan. srangwala01@gmail.com.
Muhammad Ashir ShafiqueDepartment of Medicine, Jinnah Sindh Medical University, Karachi, Pakistan.
Muhammad Saqlain MustafaDepartment of Medicine, Jinnah Sindh Medical University, Karachi, Pakistan.
Ritesh KumarBilawal Medical College for Boys Main LUMHS, Jamshoro, Sindh, Pakistan.
Janta DeviLiaquat University of Medical & Health Sciences, Sindh, Jamshoro, Pakistan.
Burhanuddin Sohail RangwalaDepartment of Medicine, Jinnah Sindh Medical University, Karachi, Pakistan.
Syed Muhammad Sinaan AliDepartment of Medicine, Liaquat National Hospital and Medical College, Karachi, Sindh, Pakistan.
Adarsh RajaDepartment of Medicine, Shaheed Mohtarma Benazir Bhutto Medical College, Larkana, Sindh, Pakistan.
Javed IqbalDepartment of Neurosurgery, University of Chicago, Chicago, IL, USA.
Mirha AliDepartment of Medicine, Jinnah Sindh Medical University, Karachi, Pakistan.
Abdul HaseebDepartment of Medicine, Jinnah Sindh Medical University, Karachi, Pakistan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glioblastoma (GB), the most common malignant brain tumour, has a poor prognosis despite advances in treatment. Standard management involves surgery followed by chemoradiotherapy. MRI-guided laser interstitial thermal therapy (LITT) is a minimally invasive technique that may offer an option for select patients with specific clinical profiles. While preclinical studies suggest that LITT could disrupt the blood-brain barrier (BBB) to enhance drug delivery, this has yet to be definitively demonstrated in clinical settings. Adhering to the PRISMA guidelines, various databases were searched until March 2024. Eligible studies focused on LITT for supratentorial GB in adults and evaluated its safety and efficacy. Data extraction covered various study characteristics, and statistical analysis was performed using the OpenMeta Analyst software. Quality assessment was performed using the Newcastle-Ottawa Scale. Fifteen studies were analyzed, mainly employing the Neuroblate-Monteris system in the US, as retrospective single-centre trials. Treatment involved LITT in 239 patients with tumours typically in deep-seated areas. Median OS ranged from 4.9 to 32.3 months, and PFS from two to 5.9 months. Most patients received adjuvant therapy, primarily radiation and temozolomide. While LITT showed efficacy in improving OS (10.21, 95% CI 9.05-11.37), PFS (3.94, 95% CI 3.20-4.69), and tumor volume reduction (18.23, 95% CI 14.591-21.860), complications odd-ration(OR) = 0.336 (95% CI, 0.188-0.484) and mortality rates OR = 0.033 (95% CI, 0.009-0.058 were notable. LITT shows promise for treating both newly diagnosed and recurrent GB cases in non-surgical candidates, linked to improved OS, PFS, reduced tumor volume, and shorter hospital stays. However, higher complication and mortality rates were noted, emphasising the need for additional well-designed prospective multicentre trials.

Indexed as

Brain NeoplasmsGlioblastomaLaser TherapyNeoplasm Recurrence, LocalHumansTreatment OutcomeGlioblastomaLaser interstitial thermal therapySafety outcomesSurvival outcomes

Identifiers

PMID39528836

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.