Evidence map›Paper›PMID 39528779›Full record

ArticleJournal of cancer survivorship : research and practice2026

Baseline predictors associated with successful weight loss among breast cancer survivors in the Lifestyle, Exercise, and Nutrition (LEAN) study.

Rachel Hoobler, Leah S Puklin, Maura Harrigan, Brenda Cartmel, Fang-Yong Li, Tara Sanft, Leah M Ferrucci, Melinda L Irwin, Mary C Playdon

Abstract read
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In one paragraph

Article in Journal of cancer survivorship : research and practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Rachel HooblerDepartment of Nutrition & Integrative Physiology, University of Utah, Salt Lake City, UT, USA.
Leah S PuklinDepartment of Chronic Disease Epidemiology, Yale School of Public Health, Yale University, New Haven, CT, USA.
Maura HarriganDepartment of Chronic Disease Epidemiology, Yale School of Public Health, Yale University, New Haven, CT, USA.
Brenda CartmelDepartment of Chronic Disease Epidemiology, Yale School of Public Health, Yale University, New Haven, CT, USA.
Fang-Yong LiDepartment of Chronic Disease Epidemiology, Yale School of Public Health, Yale University, New Haven, CT, USA.
Tara SanftCancer Prevention and Control, Yale Cancer Center, New Haven, CT, USA.
Leah M FerrucciDepartment of Chronic Disease Epidemiology, Yale School of Public Health, Yale University, New Haven, CT, USA.
Melinda L IrwinDepartment of Chronic Disease Epidemiology, Yale School of Public Health, Yale University, New Haven, CT, USA.
Mary C PlaydonDepartment of Nutrition & Integrative Physiology, University of Utah, Salt Lake City, UT, USA. mary.playdon@hci.utah.edu.

Funding

Yale Pathology Tissue Services Shared ResourceP30CA016359 · NCI · YALE UNIVERSITY · PI Eric P. Winer · 1985 to 2026
$85.0M
Yale University Clinical and Translational Science Award ProgramUL1TR000142 · NCATS · YALE UNIVERSITY · PI SHERWIN, ROBERT S · 2012 to 2015
$31.8M
Blood metabolite profiles and risk of developing endometrial cancerR00CA218694 · NCI · UNIVERSITY OF UTAH · PI PLAYDON, MARY CHRISTINE · 2018 to 2020
$747k
FUNCTIONAL CHARACTERIZATION OF ISOLATED PDGF RECEPTORR01CA040214 · NCI · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI OWEN, ALBERT J · 1985 to 1987
–
Huntsman Cancer Institute, University of Utah P30CA040214NCATS NIH HHS UL1 TR000142NCI NIH HHS 5R00CA218694-03NCI NIH HHS P30 CA016359
6 · The paper itself

Abstract

purposeTo investigate participant characteristics associated with clinically meaningful weight loss (≥ 5% weight loss) among breast cancer survivors participating in the Lifestyle, Exercise, and Nutrition (LEAN) study.

methodsFemale breast cancer survivors with a body mass index ≥ 25 kg/m

resultsBaseline data were available for 77 participants. Having a history of weight gain during breast cancer treatment was associated with lower odds of achieving ≥ 5% weight loss (OR = 0.36, 95% CI 0.13 - 0.99) compared to women with no history of weight gain during cancer treatment.

conclusionBreast cancer survivors with overweight or obesity who gained weight during their cancer treatment were less likely to achieve clinically meaningful weight loss during a post-treatment weight loss intervention. IMPLICATION FOR CANCER SURVIVORS: Breast cancer survivors are encouraged to achieve and maintain a healthy body weight to minimize the risk for cancer recurrence and comorbidity. Our results indicate that programs aimed at prevention of weight gain during treatment could aid in this goal. Understanding characteristics that increase or decrease the likelihood of achieving clinically meaningful weight loss will inform the design of programs that better support breast cancer survivors' weight loss success.

Indexed as

Breast NeoplasmsCancer SurvivorsExerciseWeight LossAdultAgedBody Mass IndexFemaleHumansLife StyleMiddle AgedObesityWeight Reduction ProgramsBaseline predictorsBreast cancerLifestyle interventionWeight loss

Identifiers

PMID39528779

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.