Evidence map›Paper›PMID 39528758›Full record

ArticlePhotochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology2024

Assessment of therapeutic response to photodynamic therapy with the Zn-Phthalocyanine RLP068/Cl versus topical Clindamycin in patients affected by Hidradenitis Suppurativa: a comparative clinical pilot study.

E Rosi, F Prignano, S Viola, M Venturini, N Pimpinelli, P Calzavara-Pinton

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

E Rosi *Department of Health Sciences, Section of Dermatology, University of Florence, Florence, Italy.
F Prignano *Department of Health Sciences, Section of Dermatology, University of Florence, Florence, Italy.
S ViolaDermatology Department, ASST Spedali Civili and University of Brescia, Brescia, Italy.
M VenturiniDermatology Department, ASST Spedali Civili and University of Brescia, Brescia, Italy.
N PimpinelliDepartment of Health Sciences, Section of Dermatology, University of Florence, Florence, Italy.
P Calzavara-PintonDermatology Department, ASST Spedali Civili and University of Brescia, Brescia, Italy. piergiacomo.calzavarapinton@unibs.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hidradenitis suppurativa is a chronic skin disorder characterized by painful inflammatory nodules and abscesses, significantly impacting patients' quality of life. Current treatment strategies, including topical antibiotics, often yield limited efficacy and pose risks of antibiotic resistance. Photodynamic therapy has emerged as a potential option, with RLP068/Cl (ELKOFAST®, non-sterile formulation) showing promising efficacy due to its broad-spectrum bactericidal activity. We conducted a pilot study assessing the therapeutic response to photodynamic therapy with RLP068/Cl versus topical clindamycin gel in patients affected by hidradenitis suppurativa of Hurley score I, II, and III. Results revealed higher efficacy of photodynamic therapy in combination with RLP068/Cl, particularly in mild cases. Its efficacy remains reliable even in more severe cases when combined with adalimumab. The observed faster lesion improvement and pain relief were ascribed to the bactericidal effects of RLP068/Cl against Gram

Indexed as

Anti-Bacterial AgentsClindamycinHidradenitis SuppurativaIndolesPhotochemotherapyPhotosensitizing AgentsAdministration, TopicalAdultFemaleHumansIsoindolesMaleMiddle AgedOrganometallic CompoundsPilot ProjectsAnti-Bacterial AgentsClindamycinIndolesIsoindolesOrganometallic CompoundsPhotosensitizing AgentsphthalocyanineAntibiotic stewardshipBactericidal activityHidradenitis suppurativaNon-sterile RLP068/ClPain reliefPhotodynamic therapy

Identifiers

PMID39528758

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.