ArticleVeterinary clinical pathology2024
Evaluation of serum protein electrophoresis and immunofixation in dogs seropositive for various vector-borne pathogens.
Article in Veterinary clinical pathology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Updated Canine Leishmaniosis Working Group recommendations for leishmaniosis in dogs: Q&A on clinical management.Parasites & vectors · 2026Review
- Impact of single versus multiple infection on serum protein fractions in cats.Veterinary research communications · 2025Article
- Evaluation of serum protein electrophoresis and immunofixation in dogs seropositive for various vector-borne pathogens.Veterinary clinical pathology · 2024Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCanine vector-borne diseases (VBDs) induce non-specific dysproteinemias, detectable by serum protein electrophoresis (SPE). VBDs have been reported to induce a monoclonal gammopathy pattern. Monoclonal gammopathies are commonly the result of paraprotein (M-protein) produced by an immunoglobulin-secreting neoplasm.
objectivesThe aims of this study were to characterize and compare SPE and immunofixation (IF) changes, evaluate the performance of previously identified SPE and IF interpretative criteria, and identify M-proteins in a cohort of dogs seropositive for a VBD and with an unknown history for an immunoglobulin-secreting neoplasm.
methodsA total of 143 serum samples from dogs that tested seropositive for different vector-borne pathogens were assessed by SPE. Cases with abnormal globulin fractions were further characterized by IF. Protein fraction and IF labeling results were evaluated using Kruskal-Wallis with Dunn's multiple comparisons and principal component analysis (PCA).
resultsIF was performed in 112 VBD-seropositive samples with dysproteinemia evaluated by SPE. Most (84/112, 75%) had a polyclonal expansion. Only two dogs had findings suggestive of an M-protein when considering both SPE and immunofixation. PCA clustered E.canis/A.phagocytophilum and B.gibsoni/CM.haematoparvum groups with relatively more γ-globulins than albumin and α-globulins, and the B.gibsoni/CM.haematoparvum group with more prominent IgA and IgM labeling than IgG labeling. Additionally, D.immitis clustered with more prominent β-globulins than γ-globulins and more IgG4 than IgG-FC.
conclusionsThe previously derived interpretative criteria suggested an M-protein in very few VBD-seropositive dogs. PCA identified SPE and immunofixation pattern differences between dogs seropositive for different infectious agents.
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